Delivery of curcumin by a pH-responsive chitosan mesoporous silica nanoparticles for cancer treatment

Nasab, N.A. and Kumleh, H.H. and Beygzadeh, M. and Teimourian, S. and Kazemzad, M. (2018) Delivery of curcumin by a pH-responsive chitosan mesoporous silica nanoparticles for cancer treatment. Artificial Cells, Nanomedicine and Biotechnology, 46 (1).

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Abstract

Mesoporous silica nanocarriers as accommodate drug molecule capsules were synthesized and capped by chitosan natural polymer. This nanocarrier acts as a pH-responsive shield to increase the solubility and improvement of anticancer properties of curcumin against U87MG glioblastoma cancer cell line. The encapsulation efficiency and drug-loading content were measured 88.1 ± 4.76 and 8.81 ± 0.47, respectively. The curcumin release from the CS-MCM-41 was slow and sustained at low pH (42.72 ± 2.29) compared to the environment pH (19.54 ± 1.36) in 96 h. The MTT evaluations showed that IC50 after 72 h treatment with free curcumin and curcumin-loaded CS-MCM-41 were 15.20 and 5.21 lg/mL (p<0.05). respectively. © 2017 Informa UK Limited, trading as Taylor & Francis Group.

Item Type: Article
Additional Information: cited By 7
Uncontrolled Keywords: Cell culture; Chitosan; Controlled drug delivery; Diseases; Drug delivery; Encapsulation; Medical nanotechnology; Silica nanoparticles; Synthesis (chemical); Targeted drug delivery, Anticancer properties; Cancer cell lines; Cancer therapy; Drug molecules; Encapsulation efficiency; Mesoporous Silica; Mesoporous silica nanoparticles; pH sensitive, Mesoporous materials, curcumin; mesoporous silica nanoparticle; antineoplastic agent; chitosan; curcumin; drug carrier; MCM-41; nanoparticle; silicon dioxide, adsorption; antineoplastic activity; aqueous solution; Article; cancer therapy; colorimetry; comparative study; controlled drug release; cytotoxicity assay; desorption; drug capsule; drug cytotoxicity; drug delivery system; drug screening; drug synthesis; field emission scanning electron microscopy; Fourier transform infrared spectroscopy; high performance liquid chromatography; human; human cell; IC50; in vitro study; MTT assay; pH; polymerization; room temperature; transmission electron microscopy; U-87MG ATCC cell line; X ray crystallography; chemistry; pH; porosity; tumor cell line, Antineoplastic Agents; Cell Line, Tumor; Chitosan; Curcumin; Drug Carriers; Humans; Hydrogen-Ion Concentration; Nanoparticles; Porosity; Silicon Dioxide
Subjects: QT Physiology
QV Pharmacology
Depositing User: eprints admin
Date Deposited: 31 Dec 2018 09:32
Last Modified: 24 Aug 2019 05:34
URI: http://eprints.iums.ac.ir/id/eprint/5869

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