Probabilistic non-carcinogenic and carcinogenic risk assessments (Monte Carlo simulation method) of the measured acrylamide content in Tah-dig using QuEChERS extraction and UHPLC-MS/MS

Shahrbabki, P.E. and Hajimohammadi, B. and Shoeibi, S. and Elmi, M. and Yousefzadeh, A. and Conti, G.O. and Ferrante, M. and Amirahmadi, M. and Fakhri, Y. and Mousavi Khaneghah, A. (2018) Probabilistic non-carcinogenic and carcinogenic risk assessments (Monte Carlo simulation method) of the measured acrylamide content in Tah-dig using QuEChERS extraction and UHPLC-MS/MS. Food and Chemical Toxicology, 118. pp. 361-370.

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Abstract

A modified �Quick, Easy, Cheap, Effective, Rugged, and Safe� QuEChERS in combination with Ultra-High Performance Liquid Chromatography/tandem mass spectrometry (UHPLC-MS/MS) method was optimized for the determination of acrylamide content in different types of tah-dig (rice, bread, and potato). Also, the non-carcinogenic and carcinogenic risks (target hazard quotient (THQ) and incremental lifetime cancer risk (ILCR)) due to ingestion of acrylamide via tah-dig in the adults and children were assessed by Monte Carlo simulation (MCS) method. The recoveries of acrylamide at five concentration levels (n = 3) ranged from 83.82 to 106.41. The repeatability of the proposed method was demonstrated with RSD in the range of 11.3�20. In addition, the limits of detection and quantification were reported as 5 ngg�1 and 15 ngg�1, respectively. The mean levels of the acrylamide contents in rice tah-dig, bread tah-dig, and potato tah-dig were measured as 24.65 ngg�1, 39.48 ngg�1, and 714.11 ngg�1, respectively. The highest acrylamide content was determined in potato tah-dig (2100 ngg�1) and the lowest acrylamide in rice tah-dig (�LOQ). Based on the conducted risk assessment, the P (95) of cumulative probability in the MCS method, the lowest and highest THQ was observed in the adults (ingestion bread tah-dig: 1.29E-2), and children (ingestion potato tah-dig: 1.90E+00), respectively. Additionally, the lowest and highest ILCR were reported in adults (ingestion bread tah-dig: 1.29E-5) and children (ingestion potato tah-dig: 7.49E-3), respectively. The rank order of type tah-dig based on THQ and ILCR for all groups of consumers was potato tah-dig > rice tah-dig > bread tah-dig. There is a considerable non-carcinogenic risk for the children due to ingestion potato tah-dig (THQ > 1). Additionally, the significant carcinogenic risk for the Iranian adults and children due to consumption of rice, bread, and potato tah-dig (ILCR > 1.00E-5) was observed. © 2018 Elsevier Ltd

Item Type: Article
Additional Information: cited By 6
Uncontrolled Keywords: acrylamide, adult; Article; calibration; cancer risk; child; concentration (parameters); controlled study; correlation coefficient; human; limit of detection; limit of quantitation; linear system; mass spectrometry; measurement repeatability; Monte Carlo method; probability; risk assessment; risk factor; solid phase extraction; ultra performance liquid chromatography
Subjects: QZ Pathology
Depositing User: eprints admin
Date Deposited: 29 Dec 2018 10:40
Last Modified: 21 Aug 2019 08:19
URI: http://eprints.iums.ac.ir/id/eprint/5871

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