Ellagic acid mitigates sodium arsenite-induced renal and hepatic toxicity in male Wistar rats

Mehrzadi, S. and Fatemi, I. and Malayeri, A.R. and Khodadadi, A. and Mohammadi, F. and Mansouri, E. and Rashno, M. and Goudarzi, M. (2018) Ellagic acid mitigates sodium arsenite-induced renal and hepatic toxicity in male Wistar rats. Pharmacological Reports, 70 (4). pp. 712-719.

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Abstract

Background: The aim of this study was to investigate the effect of ellagic acid (EA) on arsenic-induced renal and hepatic toxicity in rats. Methods: A total number of 35 male Wistar rats were randomly divided into five experimental groups. Group 1 received normal saline (po). Group 2 received sodium arsenite (SA, 10 mg/kg, po) for 21 days. Group 3 received EA (30 mg/kg, po) for 14 days. Groups 4 and 5 received SA 7 days prior to EA (10 and 30 mg/kg respectively) treatment and continued up to 21 days simultaneous with SA administration. Various biochemical, histological and molecular biomarkers were measured in kidney and liver. Results: Treatment with EA (more potently at dose of 30 mg/kg) restored the SA-induced alterations in serum creatinine (Cr) and blood urine nitrogen (BUN) levels as well as the changes in aspartate aminotransferase (AST), alkaline phosphatase (ALP) and alanine aminotransferase (ALT) concentrations (all p < 0.001). Elevated levels of malondialdehyde (MDA) and nitric oxide (NO) in renal and hepatic tissue was reduced by EA treatment (all p < 0.001). Treatment with EA enhanced the glutathione (GSH) content in liver (p < 0.001) and up-regulated renal and hepatic superoxide dismutase (SOD) and glutathione peroxidase (GPx) mRNA expression (all p < 0.001). The SA-induced histopathological alterations in kidney and liver were reduced by EA treatment. Conclusion: In conclusion, the presence of EA with SA alleviated its toxic effects and EA treatment might be an effective strategy for the management of arsenic-induced renal and hepatic damage. © 2018 Institute of Pharmacology, Polish Academy of Sciences

Item Type: Article
Additional Information: cited By 2
Subjects: WK Endocrine System
WJ Urogenital System
QV Pharmacology
Depositing User: eprints admin
Date Deposited: 31 Dec 2018 07:33
Last Modified: 31 Dec 2018 07:33
URI: http://eprints.iums.ac.ir/id/eprint/5932

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