The possible neuroprotective effect of ellagic acid on sodium arsenate-induced neurotoxicity in rats

Goudarzi, M. and Amiri, S. and Nesari, A. and Hosseinzadeh, A. and Mansouri, E. and Mehrzadi, S. (2018) The possible neuroprotective effect of ellagic acid on sodium arsenate-induced neurotoxicity in rats. Life Sciences, 198. pp. 38-45.

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Abstract

Objective: Arsenic is a well-known environmental contaminant, causing toxicity in different organs. The aim of this study was to investigate the possible neuroprotective effect of ellagic acid (EA) on arsenic-induced neurotoxicity in rats. Design: Animals were divided into five groups. The first group received normal saline (2 mL/kg) for 21 days as control group. Group 2 was orally treated with sodium arsenite (SA, 10 mg/kg) for 21 days. Groups 3 and 4 were orally treated with SA (10 mg/kg) for 7 days prior to EA (10 and 30 mg/kg respectively) treatment and continued up to 21 days simultaneously with SA administration. Group 5 was orally treated with EA (30 mg/kg) for 14 days. Passive avoidance test and rotarod test were done to evaluate the behavioral changes following SA and/or EA treatment. Different biochemical, histological and molecular biomarkers were assessed in the brain tissue. Results: Our data showed that SA significantly elevated brain tissue arsenic levels and malondialdehyde, nitric oxide, protein carbonylation, tumor necrosis factor-alpha, and interlukein-1β production. A decrease in the total antioxidant capacity, reduced glutathione content and glutathione peroxidase activity occurred in the brain of rats exposed to SA. SA-treated rats showed a significant impairment in long-term-memory, motor coordination and equilibrium. These results were supported by histopathological observations of the brain. Results revealed that administration of EA (30 mg/kg) reversed all neural markers alternation and ameliorated behavioral and histopathological changes induced by SA. Conclusion: EA can effectively protect brain tissue against SA-induced neurotoxicity via its antioxidant and anti-inflammatory effects. © 2018 Elsevier Inc.

Item Type: Article
Additional Information: cited By 2
Uncontrolled Keywords: arsenate sodium; ellagic acid; glutathione; glutathione peroxidase; interleukin 1beta; malonaldehyde; nitric oxide; tumor necrosis factor; antioxidant; arsenate sodium; arsenic acid derivative; ellagic acid; glutathione peroxidase; IL1B protein, rat; interleukin 1beta; neuroprotective agent; nitric oxide; tumor necrosis factor, adult; animal experiment; animal model; animal tissue; Article; behavior change; brain tissue; controlled study; cytokine production; drug effect; histopathology; long term memory; male; motor coordination; neuroprotection; neurotoxicity; nonhuman; passive avoidance test; protein carbonylation; psychological balance; rat; rotarod test; animal; animal behavior; brain; brain injury; chemistry; drug effects; maze test; metabolism; oxidation reduction reaction; oxidative stress; Wistar rat, Animals; Antioxidants; Arsenates; Behavior, Animal; Brain; Brain Injuries; Ellagic Acid; Glutathione Peroxidase; Interleukin-1beta; Male; Maze Learning; Neuroprotective Agents; Nitric Oxide; Oxidation-Reduction; Oxidative Stress; Rats; Rats, Wistar; Tumor Necrosis Factor-alpha
Subjects: WL Nervous System
QV Pharmacology
Depositing User: eprints admin
Date Deposited: 26 Dec 2018 08:32
Last Modified: 21 Aug 2019 05:56
URI: http://eprints.iums.ac.ir/id/eprint/5946

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