Dioxin exposure in the manufacture of pesticide production as a risk factor for death from prostate cancer: A meta-analysis

Kabir, A. and Zendehdel, R. and Tayefeh-Rahimian, R. (2018) Dioxin exposure in the manufacture of pesticide production as a risk factor for death from prostate cancer: A meta-analysis. Iranian Journal of Public Health, 47 (2). pp. 148-155.

[img] Text
IJPH-47-148.pdf

Download (733kB)
Official URL: https://www.scopus.com/inward/record.uri?eid=2-s2....

Abstract

Background: In pesticide exposure groups such as farmers, the risk of prostate cancer was increased, although the report of the cause of evidence is limited. We selected chlorophenol compounds as an important group of the contaminated pesticide with highly toxic 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin (TCDD). This meta-analysis, the risk of death from prostate cancer was analyzed. Methods: PubMed, Scopus, Scholar Google and web of Sciences until 2016 were searched. The standardized mortality rate (SMR) and 95 confidence intervals (CI) were obtained from the studies. We tested statistical heterogeneity with Cochrane Q test and I2 index. Egger test was used for evaluating publication bias. Random or fixed-effects models and meta-regression were also used in our analysis. Moreover, Cochrane tool was used to assess the risk of bias. Results: Five available papers consist of 28706 exposed populations were assessed. Overall standardized mortality rate as combined result of prostate cancer risk from the fixed model was 1.2 (95 confidence interval (CI) 1.02 to 1.42, P=0.027). Some biases are more probable in these studies such as confounding by indication, loss to follow up and misclassification. Conclusion: A contaminated pesticide with dioxins between other pesticides is an important risk factor for prostate cancers. © 2018, Iranian Journal of Public Health. All rights reserved.

Item Type: Article
Additional Information: cited By 2
Subjects: WJ Urogenital System
QV Pharmacology
Depositing User: eprints admin
Date Deposited: 31 Dec 2018 08:34
Last Modified: 22 Jun 2019 07:18
URI: http://eprints.iums.ac.ir/id/eprint/5957

Actions (login required)

View Item View Item