Daptomycin

Heidary, M. and Khosravi, A.D. and Khoshnood, S. and Nasiri, M.J. and Soleimani, S. and Goudarzi, M. (2018) Daptomycin. Journal of Antimicrobial Chemotherapy, 73 (1). pp. 1-11.

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Abstract

Daptomycin is a cyclic lipopeptide antibiotic used for the treatment of Gram-positive infections including complicated skin and skin structure infections, right-sided infective endocarditis, bacteraemia, meningitis, sepsis and urinary tract infections. Daptomycin has distinct mechanisms of action, disrupting multiple aspects of cell membrane function and inhibiting protein, DNA and RNA synthesis. Although daptomycin resistance in Grampositive bacteria is uncommon, there are increasing reports of daptomycin resistance in Staphylococcus aureus, Enterococcus faecium and Enterococcus faecalis. Such resistance is seen largely in the context of prolonged treatment courses and infections with high bacterial burdens, but may occur in the absence of prior daptomycin exposure. Furthermore, use of inadequate treatment regimens, irregular drug supply and poor drug quality have also been recognized as other important risk factors for emergence of daptomycin-resistant strains. Antimicrobial susceptibility testing of Gram-positive bacteria, communication between clinicians and laboratories, establishment of internet-based reporting systems, development of better and more rapid diagnostic methods and continuous monitoring of drug resistance are urgent priorities. © The Author 2017. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved.

Item Type: Article
Additional Information: cited By 2
Uncontrolled Keywords: ampicillin; beta lactam antibiotic; daptomycin; gentamicin; oxacillin; rifampicin; antiinfective agent; daptomycin, antibiotic resistance; biofilm; drug mechanism; drug potentiation; drug structure; Enterococcus faecalis; Enterococcus faecium; human; immunomodulation; methicillin resistant Staphylococcus aureus; nonhuman; Review; risk factor; Staphylococcus aureus; vancomycin resistant Enterococcus; bacteremia; drug effect; Gram positive bacterium; Gram positive infection; microbial sensitivity test; microbiology; physiology, Anti-Bacterial Agents; Bacteremia; Biofilms; Daptomycin; Drug Resistance, Bacterial; Gram-Positive Bacteria; Gram-Positive Bacterial Infections; Humans; Microbial Sensitivity Tests
Subjects: WC Communicable Diseases
QV Pharmacology
Depositing User: eprints admin
Date Deposited: 31 Dec 2018 09:36
Last Modified: 24 Aug 2019 05:41
URI: http://eprints.iums.ac.ir/id/eprint/5977

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