Synthesis and antagonistic activity of four new 2-alkyl-N-biphenyl fused imidazoles on angiotensin II receptors

Akhavan, M.M. and Mojarrad, J.S. and Rouzrokh, A. and Ebrahimi, S.A. and Mahmoudian, M. and Shafiee, A. (2003) Synthesis and antagonistic activity of four new 2-alkyl-N-biphenyl fused imidazoles on angiotensin II receptors. Farmaco, 58 (11). pp. 1193-1199.

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Abstract

In the current study, four new 2-alkyl-N-biphenyl fused imidazoles were synthesized and the pharmacological properties of these compounds as angiotensin II antagonists were studied. First, the potency of the synthesized compounds on guinea-pig ileum was evaluated and the vasopressor effect of the most potent compound 6a was compared with losartan on isolated perfused rat kidney. The antagonistic activity of compound 6a (sodium 2-propyl-5- carbomethoxy-1-(biphenyl-4-yl)methylpyrrolo3,2-dimidazole-2�- carboxylate) on angiotensin II receptors was greater than the other synthesized compounds and in isolated perfused rat kidney was similar to losartan. © 2003 �ditions scientifiques et médicales Elsevier SAS. All rights reserved.

Item Type: Article
Additional Information: cited By 5
Uncontrolled Keywords: angiotensin 2 receptor; angiotensin 2 receptor antagonist; dicarboxylic acid derivative; imidazole derivative; losartan; sodium 2 butyl 5 carbomethoxy 1 (biphenyl 4 yl)methylpyrrolo3,2 dimidazole 2' carboxylate; sodium 2 propyl 5 carbomethoxy 1 (biphenyl 4 yl)methylpyrrolo3,2 dimidazole 2' carboxylate; unclassified drug, animal tissue; article; controlled study; drug antagonism; drug effect; drug potency; drug synthesis; guinea pig; ileum; isolated kidney; male; nonhuman; rat, Angiotensin II; Animals; Dose-Response Relationship, Drug; Guinea Pigs; Imidazoles; Male; Rats; Rats, Wistar; Receptors, Angiotensin; Vasoconstriction
Depositing User: EPrints System Admin
Date Deposited: 19 Jul 2017 10:13
Last Modified: 19 Jul 2017 10:13
URI: http://eprints.iums.ac.ir/id/eprint/60

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