Plant protein-based hydrophobic fine and ultrafine carrier particles in drug delivery systems

Malekzad, H. and Mirshekari, H. and Sahandi Zangabad, P. and Moosavi Basri, S.M. and Baniasadi, F. and Sharifi Aghdam, M. and Karimi, M. and Hamblin, M.R. (2018) Plant protein-based hydrophobic fine and ultrafine carrier particles in drug delivery systems. Critical Reviews in Biotechnology, 38 (1). pp. 47-67.

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For thousands of years, plants and their products have been used as the mainstay of medicinal therapy. In recent years, besides attempts to isolate the active ingredients of medicinal plants, other new applications of plant products, such as their use to prepare drug delivery vehicles, have been discovered. Nanobiotechnology is a branch of pharmacology that can provide new approaches for drug delivery by the preparation of biocompatible carrier nanoparticles (NPs). In this article, we review recent studies with four important plant proteins that have been used as carriers for targeted delivery of drugs and genes. Zein is a water-insoluble protein from maize; Gliadin is a 70 alcohol-soluble protein from wheat and corn; legumin is a casein-like protein from leguminous seeds such as peas; lectins are glycoproteins naturally occurring in many plants that recognize specific carbohydrate residues. NPs formed from these proteins show good biocompatibility, possess the ability to enhance solubility, and provide sustained release of drugs and reduce their toxicity and side effects. The effects of preparation methods on the size and loading capacity of these NPs are also described in this review. © 2017 Informa UK Limited, trading as Taylor & Francis Group.

Item Type: Article
Additional Information: cited By 1
Uncontrolled Keywords: Biocompatibility; Drug interactions; Drug products plants; Proteins; Seed; Targeted drug delivery; Zein, delivery; drug; gliadin; lectin; Legumin; Nano-carriers; Plant; release; Sustained, Controlled drug delivery, avenin; drug; gliadin; lectin; nanocarrier; nanofiber; plant protein; soybean protein; vicilin; zein; gliadin; legumin protein, plant; plant protein; recombinant protein; zein, electrospinning; hydrophobicity; legume; nonhuman; particle size; phase separation; priority journal; protein isolation; protein structure; Review; animal; chemical phenomena; drug delivery system; human; mouse; nanomedicine; particle size, Animals; Drug Delivery Systems; Gliadin; Humans; Hydrophobic and Hydrophilic Interactions; Mice; Nanomedicine; Particle Size; Plant Proteins; Recombinant Proteins; Zein
Subjects: QV Pharmacology
Depositing User: eprints admin
Date Deposited: 25 Dec 2018 15:43
Last Modified: 25 Dec 2018 15:43

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