The effect of intrathecal injection of irisin on pain threshold and expression rate of GABAB receptors in peripheral neuropathic pain model

Dameni, S. and Janzadeh, A. and Yousefifard, M. and Nasirinezhad, F. (2018) The effect of intrathecal injection of irisin on pain threshold and expression rate of GABAB receptors in peripheral neuropathic pain model. Journal of Chemical Neuroanatomy, 91. pp. 17-26. (In Press)

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Background: and aim: Irisin is a new myokine that is secreted by myocytes during exercise, and plays a role in creating the beneficial effects of exercise on metabolism. Considering the benefits of exercise in reducing pain, this study was carried out to determine the probable effect of irisin on neuropathic pain in the chronic constriction injury (CCI) model in male rats. Methods: To induce neuropathic pain CCI model was used. Animals were divided into groups of control, CCI, sham, CCI + vehicle, and CCI + irisin. Animals that had undergone CCI were divided into 6 groups and each received a different intrathecal dose of irisin (30, 10, 3, 1, 0.3, and 0.1 μg/kg) via intrathecal administration. To evaluate the chronic effect of irisin, its effective dose was injected for 14 days in another group of animals. At the end of the experiment, animals were ranscardially perfused and their spinal cord tissue was prepared for immunohistochemical and hematoxylin-eosin staining. Results: The results showed that in acute intrathecal injection of irisin, 1 μg/kg dose has the highest analgesic effect compared to other doses. Nevertheless, in chronic administration of irisin with 1 μg/kg dose, no analgesic effect was detected. In addition, irisin administration could not increase the expression level of GABAB1 and B2 or prevent the decline in the number of neurons. Conclusion: The findings of the present study showed that acute administration of Irisin increases the pain threshold, but the chronic injection of resin does not have an effect on pain reduction and the expression of GABA receptors and it seems that this peptide is not a proper replacement for exercise in patients with neuropathic pain, who cannot exercise. © 2018

Item Type: Article
Additional Information: cited By 0
Uncontrolled Keywords: 4 aminobutyric acid B receptor; irisin, adult; allodynia; analgesia; analgesic activity; animal experiment; animal model; animal tissue; Article; cell count; chronic constriction injury; chronic drug administration; cold allodynia; comparative study; controlled study; heat hyperalgesia; hyperalgesia; immunohistochemistry; male; mechanical hyperalgesia; neuropathic pain; nonhuman; pain assessment; pain threshold; priority journal; protein expression; rat; sciatic nerve injury
Subjects: WK Endocrine System
QV Pharmacology
Depositing User: eprints admin
Date Deposited: 24 Dec 2018 10:33
Last Modified: 19 Aug 2019 07:16

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