Rutin, a quercetin glycoside, alleviates acute endotoxemic kidney injury in C57BL/6 mice via suppression of inflammation and up-regulation of antioxidants and SIRT1

Khajevand-Khazaei, M.-R. and Mohseni-Moghaddam, P. and Hosseini, M. and Gholami, L. and Baluchnejadmojarad, T. and Roghani, M. (2018) Rutin, a quercetin glycoside, alleviates acute endotoxemic kidney injury in C57BL/6 mice via suppression of inflammation and up-regulation of antioxidants and SIRT1. European Journal of Pharmacology, 833. pp. 307-313.

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Abstract

Acute kidney injury (AKI) is a common complication following severe sepsis, its incidence is increasing, and it is associated with a high rate of morbidity and mortality. Rutin is a glycoside of the bioflavonoid quercetin with various protective effects due to its antioxidant and anti-inflammatory potential. In this research, we tried to assess the protective effect of rutin administration in a model of AKI in C57BL/6 mice. For induction of AKI, lipopolysaccharide (LPS) was injected once (10 mg/kg, i.p.) and rutin was p.o. given at doses of 50 or 200 mg/kg. Treatment of LPS-challenged group with rutin lowered serum level of creatinine and blood urea nitrogen (BUN), restored to some extent renal oxidative stress-related indices such as malondialdehyde (MDA), glutathione (GSH), and activity of superoxide dismutase (SOD) and catalase. In addition, rutin brought back renal nuclear factor-kappaB (NF-κB), toll-like receptor 4 (TLR4), cyclooxygenase-2 (COX2), sirtuin 1 (SIRT1), tumor necrosis factor α (TNFα), interleukin-6, and caspase 3 activity to their control levels. Moreover, protective effect of rutin was in accordance to a dose-dependent manner. Collectively, rutin is capable to mitigate LPS-induced AKI via appropriate modulation of renal oxidative stress, inflammation, and apoptosis. © 2018 Elsevier B.V.

Item Type: Article
Additional Information: cited By 0
Uncontrolled Keywords: caspase 3; catalase; creatinine; cyclooxygenase 2; glutathione; immunoglobulin enhancer binding protein; interleukin 6; lipopolysaccharide; malonaldehyde; nitrogen; rutoside; sirtuin 1; superoxide dismutase; toll like receptor 4; tumor necrosis factor; urea, acute kidney failure; animal experiment; animal model; antiinflammatory activity; antioxidant activity; apoptosis; Article; C57BL 6 mouse; concentration response; controlled study; creatinine blood level; drug dose comparison; enzyme activity; female; mouse; nonhuman; oxidative stress; priority journal; urea nitrogen blood level
Subjects: WJ Urogenital System
QV Pharmacology
Depositing User: eprints admin
Date Deposited: 24 Dec 2018 09:59
Last Modified: 18 Aug 2019 09:47
URI: http://eprints.iums.ac.ir/id/eprint/6301

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