The Drosha rs10719 T>C polymorphism is associated with preeclampsia susceptibility

Rezaei, M. and Eskandari, F. and Mohammadpour-Gharehbagh, A. and Teimoori, B. and Yaghmaei, M. and Mokhtari, M. and Salimi, S. (2018) The Drosha rs10719 T>C polymorphism is associated with preeclampsia susceptibility. Clinical and Experimental Hypertension, 40 (5). pp. 440-445.

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Abstract

Purpose: Drosha is a member of the micro RNA (miRNA) processing machinery that affects miRNA processing. Single-nucleotide polymorphisms (SNPs) in the Drosha gene might affect microRNA processing and the expression of various genes. The aim of this study is to investigate the association between SNPs in the Drosha gene and preeclampsia (PE) in the southeast of Iran. Methods: Genotyping of Drosha rs10719 and rs6877842 was performed using blood samples from 219 PE women and 205 healthy control subjects by a polymerase chain reaction-restriction fragment length polymorphism method. Results: The Drosha rs10719TC genotype was significantly associated with 1.6-fold higher risk of PE (odds ratio (OR, 1.6 95% CI, 1.1�2.4, P = 0.026). In addition, the frequency of the Drosha rs10719CC genotype was significantly higher in PE women and was associated with threefold higher risk of PE (OR 3 95% CI 1.4�6.3, P = 0.004). There was no association between the Drosha rs6877842 polymorphism and PE susceptibility. The CC�GG combined genotype was associated with 3.4-fold higher risk of PE (OR 3.4 95% CI 1.4�8.1, P = 0.007). The haplotype-based association analysis showed higher frequency of C�G haplotype of Drosha rs10719 and rs6877842 polymorphisms with the increased risk of PE 1.5-fold (OR 1.5 95% CI 1.1�2, P = 0.01). Conclusions: The Drosha rs10719TC and CC genotypes were associated with PE risk. The CC�GG combined genotype and C�G haplotype of Drosha rs10719 and rs6877842 polymorphisms may increase PE susceptibility. © 2018 Taylor & Francis.

Item Type: Article
Additional Information: cited By 0
Uncontrolled Keywords: microRNA; restriction endonuclease, adult; Article; blood sampling; controlled study; Drosha gene; female; gene; gene frequency; genetic association; genetic susceptibility; genotyping technique; haplotype; human; major clinical study; polymerase chain reaction; preeclampsia; pregnant woman; restriction fragment length polymorphism; risk assessment; RNA processing; single nucleotide polymorphism
Subjects: QV Pharmacology
Depositing User: eprints admin
Date Deposited: 24 Dec 2018 05:52
Last Modified: 24 Dec 2018 05:52
URI: http://eprints.iums.ac.ir/id/eprint/6371

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