Involvement of IL-1β and IL-6 in antiarrhythmic properties of atorvastatin in ouabain-induced arrhythmia in rats

Najjari, M. and Vaezi, G. and Hojati, V. and Mousavi, Z. and Bakhtiarian, A. and Nikoui, V. (2018) Involvement of IL-1β and IL-6 in antiarrhythmic properties of atorvastatin in ouabain-induced arrhythmia in rats. Immunopharmacology and Immunotoxicology, 40 (3). pp. 256-261.

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Abstract

Purpose: Evidence show that statins possess wide beneficial cardioprotective and anti-inflammatory effects; therefore, in the present experiment, we investigated the antiarrhythmic properties of atorvastatin in ouabain-induced arrhythmia in isolated rat atria and the role of several inflammatory cytokines in this effect. Materials and methods: Male rats were pretreated with either of atorvastatin (10 mg/kg) or vehicle, orally once daily for 6 weeks. After induction of anesthesia, we isolated the atria and after incubation with ouabain, time of onset of arrhythmia and asystole as well as atrial beating rate and contractile force were recorded. We also measured the atrial levels of IL-1β, IL-6, and TNF-α after the injection of ouabain to animals. Results: Pretreatment with atorvastatin significantly delayed the onset of arrhythmia and asystole compared with vehicle-treated group (p <.01, p <.001, respectively). Incubation of ouabain boosted both atrial beating rate and contractile force in vehicle-treated group (p <.05), while these responses in atorvastatin-treated group were not significant (p >.05). Injection of ouabain elevated the atrial levels of IL-1β, IL-6, and TNF-α, while pretreatment of animals with atorvastatin could reverse the ouabain-induced increase in atrial IL-1β and IL-6 (p <.01 and p <.05, respectively). Conclusions: It is concluded that observed antiarrhythmic effects of atorvastatin might be attributed to modulation of some inflammatory cytokines, at least IL-1β and IL-6. © 2018 Informa UK Limited, trading as Taylor & Francis Group.

Item Type: Article
Additional Information: cited By 0
Uncontrolled Keywords: atorvastatin; interleukin 1beta; interleukin 6; ouabain; tumor necrosis factor, anesthesia induction; animal experiment; antiarrhythmic activity; Article; controlled study; heart arrest; heart arrhythmia; heart muscle contractility; incubation time; male; nonhuman; priority journal; rat; treatment duration; treatment response
Subjects: QV Pharmacology
Depositing User: eprints admin
Date Deposited: 19 Dec 2018 15:17
Last Modified: 19 Dec 2018 15:17
URI: http://eprints.iums.ac.ir/id/eprint/6616

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