Comparison of tuberculin skin test and interferon gamma release assay for diagnosis of latent tuberculosis infection in pediatric candidates of renal transplantation

Sayyahfar, S. and Davoodzadeh, F. and Hoseini, R. and Rahimzadeh, N. and Otukesh, H. (2018) Comparison of tuberculin skin test and interferon gamma release assay for diagnosis of latent tuberculosis infection in pediatric candidates of renal transplantation. Pediatric Transplantation, 22 (2).

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Abstract

IGRA has been approved as an alternative in vitro test to diagnose Mycobacterium TB infection. This study aimed to assess the diagnostic value of TST in comparison with QFT assay to detect LTBI among Iranian children candidate for renal transplantation. This cross-sectional study was performed on 31 children who were candidate for renal transplantation admitted to Ali Asghar Children's Hospital and Rasoul Akram Hospital, Tehran, Iran, from 2013 to 2014. TST and QFT were performed for all patients. QFT was negative in all patients, while TST was positive only in one case. Both tests results were negative in 30 patients, yielding an accuracy rate of 96.7 for TST to diagnose LTBI when compared to QFT. In conclusion, compared to QFT, TST is still a valuable diagnostic tool with high accuracy rate for diagnosis of LTBI in children candidates for renal transplantation and can still be used as an accurate test for screening Mycobacterium TB infection. © 2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd

Item Type: Article
Additional Information: cited By 0
Uncontrolled Keywords: adolescent; Article; child; clinical article; clinical effectiveness; controlled study; cross-sectional study; diagnostic accuracy; diagnostic value; end stage renal disease; female; hospital admission; human; interferon gamma release assay; intermethod comparison; Iran; Iranian (citizen); kidney transplantation; latent tuberculosis; male; Mycobacterium tuberculosis; pediatrics; tuberculin test; clinical trial; comparative study; infant; latent tuberculosis; newborn; preoperative care; preschool child; procedures, Adolescent; Child; Child, Preschool; Cross-Sectional Studies; Female; Humans; Infant; Infant, Newborn; Interferon-gamma Release Tests; Iran; Kidney Transplantation; Latent Tuberculosis; Male; Preoperative Care; Tuberculin Test
Subjects: WJ Urogenital System
WS Pediatrics
Depositing User: eprints admin
Date Deposited: 12 Dec 2018 15:45
Last Modified: 12 Dec 2018 15:45
URI: http://eprints.iums.ac.ir/id/eprint/6835

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