Nasopharyngeal carcinoma protein interaction mapping analysis via proteomic approaches

Azodi, M.Z. and Tavirani, M.R. and Tavirani, M.R. and Vafaee, R. and Rostami-Nejad, M. (2018) Nasopharyngeal carcinoma protein interaction mapping analysis via proteomic approaches. Asian Pacific Journal of Cancer Prevention, 19 (3). pp. 845-851.

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Abstract

Nasopharyngeal carcinoma (NPC), although not very common in many parts of the world, is a major concern in some countries, including Iran. Molecular studies are very helpful to provide essential information regarding underlying carcinogenetic mechanisms. Here, considering NPC proteomic approaches, established biomarkers were designated for protein-protein interaction network construction and analysis with corresponding plug-ins. A network of reported protein markers was constructed and topological and biological process features were investigated. Centrality analysis showed that JUN, CALM1, HSB1, and SOD1 are more important than other differentially expressed proteins in an interacting pattern. What is more, by extending the network, Tp53, PRDM10, AKT1, ALB, HSP90AA1, and EGFR achieved the highest values for NPC network strength. It can be concluded that these proteins as well as their contributing processes, particularly in a second network, may be important for NPC onset and development. Targeting these candidate proteins may allow novel treatment approaches following appropriate validation. © Asian Pacific Journal of Cancer Prevention, 2017.

Item Type: Article
Additional Information: cited By 0
Uncontrolled Keywords: proteome; tumor marker, carcinoma; gene expression regulation; gene regulatory network; human; metabolism; nasopharynx tumor; pathology; procedures; protein analysis; proteomics, Biomarkers, Tumor; Carcinoma; Gene Expression Regulation, Neoplastic; Gene Regulatory Networks; Humans; Nasopharyngeal Neoplasms; Protein Interaction Mapping; Proteome; Proteomics
Subjects: WV Otolaryngology
Depositing User: eprints admin
Date Deposited: 12 Dec 2018 12:37
Last Modified: 21 Jul 2019 05:32
URI: http://eprints.iums.ac.ir/id/eprint/6855

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