The Effect of Demographic Factors and VKORC1 1639 G>A Genotypes on Estimated Warfarin Maintenance Dose in Iranian Patients Under Warfarin Therapy

Rad, F. and Hamidpour, M. and Dorgalaleh, A. and Poopak, B. (2018) The Effect of Demographic Factors and VKORC1 1639 G>A Genotypes on Estimated Warfarin Maintenance Dose in Iranian Patients Under Warfarin Therapy. Indian Journal of Hematology and Blood Transfusion.

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Abstract

Warfarin is an anticoagulant that inhibits vitamin K-dependent clotting factors including factor (F) II, FVII, FIX and FX. Different factors can change the effect of this anticoagulant in clinic. Therefore we assessed impact of VKORC1 -1639 G>A polymorphism and demographic factors on required maintenance dose in Iranian patients under warfarin therapy. The study population included 95 patients with a mean age of 61.3 ± 12.6 years. Target INR range of 2�3 was considered for these patients. The frequency of VKORC1 -1639 G>A polymorphism was assessed by polymerase chain reaction-restriction length polymorphism (PCR-RFLP). Finally the obtain data were analyzed by SPSS software. Our study revealed that 30.5, 49.5, and 20 of the patients had VKORC1 (G/G), (G/A), and (A/A) genotypes, respectively. Carriers of VKORC1 G/G genotype required a higher warfarin dose as compared to A/A carriers (4.48 ± 1.32 and 2.7 ± 1.16 mg/day, respectively; P < 0.01). In addition, patients with higher age required lower warfarin therapeutic dose (r = � 0.3, P < 0.01). It seems that -1639 G>A polymorphism and demographic variables had significant effects on warfarin maintenance dose in Iranian patients under warfarin therapy. © 2018, Indian Society of Hematology and Blood Transfusion.

Item Type: Article
Additional Information: cited By 0; Article in Press
Subjects: WG Cardiovascular System
Depositing User: eprints admin
Date Deposited: 08 Dec 2018 07:36
Last Modified: 10 Aug 2019 05:54
URI: http://eprints.iums.ac.ir/id/eprint/7052

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