Increased expression of CD44 is associated with more aggressive behavior in clear cell renal cell carcinoma

Zanjani, L.S. and Madjd, Z. and Abolhasani, M. and Rasti, A. and Fodstad, O. and Andersson, Y. and Asgari, M. (2018) Increased expression of CD44 is associated with more aggressive behavior in clear cell renal cell carcinoma. Biomarkers in Medicine, 12 (1). pp. 45-61.

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Abstract

Aim: Although CD44 has been suggested as a prognostic marker in renal cell carcinoma (RCC), the prognostic significance of this marker in three main subtypes of RCC is still unclear. Thus, the present study was conducted to evaluate the expression and prognostic significance of CD44 as a cancer stem cell marker in different histological subtypes of RCC. Methodology & results: CD44 expression was evaluated in 206 well-defined renal tumor samples using immunohistochemistry on tissue microarrays. Higher CD44 expression was associated with more aggressive behavior, tumor progression and worse prognosis in clear cell RCC (ccRCC) but not in papillary and chromophobe RCC subtypes. Discussion & conclusion: Cancer stem cell marker CD44 may be a promising target for cancer treatment only in ccRCC. © 2018 Future Medicine Ltd.

Item Type: Article
Additional Information: cited By 0
Uncontrolled Keywords: cell marker; Hermes antigen; CD44 protein, human; hyaluronic acid binding protein; tumor marker, adult; aged; Article; cancer classification; cancer growth; cancer prognosis; cancer stem cell; cancer therapy; controlled study; drug targeting; female; histopathology; human; human tissue; immunohistochemistry; major clinical study; male; protein expression; renal cell carcinoma; tissue microarray; kidney tumor; metabolism; middle aged; pathology; prognosis; renal cell carcinoma; very elderly, Adult; Aged; Aged, 80 and over; Biomarkers, Tumor; Carcinoma, Renal Cell; Female; Humans; Hyaluronan Receptors; Immunohistochemistry; Kidney Neoplasms; Male; Middle Aged; Prognosis
Subjects: WJ Urogenital System
Depositing User: eprints admin
Date Deposited: 05 Dec 2018 12:10
Last Modified: 05 Dec 2018 12:10
URI: http://eprints.iums.ac.ir/id/eprint/7134

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