Epithelial and endothelial mesenchymal transition and their role in diabetic kidney disease

Dadras, F. and Sheikh, V. and Khoshjou, F. (2018) Epithelial and endothelial mesenchymal transition and their role in diabetic kidney disease. Journal of Renal Injury Prevention, 7 (1). pp. 1-6.

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Abstract

Diabetic nephropathy (DN) is the main cause of end-stage renal disease. On the other hand, there are a couple of evidences, including human studies, which prove the role of epithelial mesenchymal transition (EMT) in pathophysiology of DN. EMT is characterized by loss of epithelial proteins and gain of mesenchymal markers. EMT is induced via three main conduit; TGF�/Smad, integrin /ILK as well as Wnt/�-catenin pathways. Besides, numerous studies illustrated how drugs and agents can modify this phenomenon. On the other hand, endothelial mesenchymal transition (EndoMT) has a well-known role in pathophysiology of diabetic nephropathy which has been studied in animal and human. Here, several drugs and modifiers which have been studied to ffigure out if they can amend nature of EMT or EndoMT are reported briefly. © 2018 The Author(s).

Item Type: Article
Additional Information: cited By 0
Subjects: WJ Urogenital System
QV Pharmacology
Depositing User: eprints admin
Date Deposited: 04 Dec 2018 12:17
Last Modified: 11 Aug 2019 10:15
URI: http://eprints.iums.ac.ir/id/eprint/7162

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