Clinical outcomes of endoscopic versus microscopic trans-sphenoidal surgery for large pituitary adenoma

Akbari, H. and Malek, M. and Ghorbani, M. and Ramak Hashemi, S.M. and Khamseh, M.E. and Zare Mehrjardi, A. and Emami, Z. and Ebrahim Valojerdi, A. (2018) Clinical outcomes of endoscopic versus microscopic trans-sphenoidal surgery for large pituitary adenoma. British Journal of Neurosurgery. pp. 1-4.

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Objective: To compare clinical outcomes of large pituitary adenomas (�3�cm in maximum diameter), operated on by Endoscopic Transsphenoidal Surgery (ETS), versus Microscopic Transsphenoidal Surgery (MTS). Methods: Medical records and MRI Scans of patients with a diagnosis of pituitary adenoma for whom transphenoidal surgery was done were reviewed. Complete pre and post-operative data were available for 121 patients. Thirty five patients had large pituitary adenoma and were enrolled in this study. ETS was done in 16 patients, and 19 underwent MTS. All patients were followed for at least six months. Clinical and imaging characteristics were reported in details. Post-operative clinical outcomes were defined as clinical outcomes persisted 6 months after surgery. Results: The average tumor size was 36.3�±�4.4�mm in ETS group, and 34.0�±�4.6�mm in MTS group, (p�=�.46). Six months after surgery, tumor size was 4.6�±�6.6�mm in ETS and 17.7�±�12.2�mm in MTS group, (p�=�.002). Gross total resection (GTR) was observed in the 81.2 of the patient in the ETS group. In the MTS group, GTR was observed in 15.8. Post-operative clinical outcomes including new onset hypopituitarism, visual impairment, and permanent diabetes insipidus (DI) were comparable between the two groups. Conclusion: ETS is superior to MTS in treatment of large pituitary adenomas with comparable post-operative complications. © 2018 The Neurosurgical Foundation

Item Type: Article
Additional Information: cited By 0; Article in Press
Depositing User: eprints admin
Date Deposited: 05 Aug 2018 03:57
Last Modified: 30 Sep 2018 10:03

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