Recurrence of primary hyperoxaluria after kidney transplantation

Malakoutian, T. and Asgari, M. and Houshmand, M. and Mohammadi, R. and Aryani, O. and Pargoo, E.M. and Ghods, A.J. (2011) Recurrence of primary hyperoxaluria after kidney transplantation. Iranian Journal of Kidney Diseases, 5 (6). pp. 429-433.

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Abstract

Primary hyperoxaluria is a genetic disorder in glyoxylate metabolism that leads to systemic overproduction of oxalate. Functional deficiency of alanine-glyoxylate aminotransferase in this disease leads to recurrent nephrolithiasis, nephrocalcinosis, systemic oxalosis, and kidney failure. We present a young woman with end-stage renal disease who received a kidney allograft and experienced early graft failure presumed to be an acute rejection. There was no improvement in kidney function, and she was required hemodialysis. Ultimately, biopsy revealed birefringent calcium oxalate crystals, which raised suspicion of primary hyperoxaluria. Further evaluations including genetic study and metabolic assay confirmed the diagnosis of primary hyperoxaluria type 1. This suggests a screening method for ruling out primary hyperoxaluria in suspected cases, especially before planning for kidney transplantation in patients with end-stage renal disease who have nephrocalcinosis, calcium oxalate calculi, or a family history of primary hyperoxaluria.

Item Type: Article
Additional Information: cited By 3
Uncontrolled Keywords: alanine aminotransferase; antibiotic agent; calcium oxalate; creatinine; cyclosporin; methylprednisolone; mycophenolic acid 2 morpholinoethyl ester; prednisolone, acute graft rejection; adult; article; blood analysis; case report; creatinine blood level; Doppler echography; family history; female; graft failure; graft rejection; hemodialysis; human; human tissue; kidney allograft; kidney biopsy; kidney calcification; kidney failure; kidney function; kidney transplantation; nephrolithiasis; oxalosis 1; sepsis, Biopsy; Diagnosis, Differential; Female; Follow-Up Studies; Humans; Hyperoxaluria, Primary; Kidney Failure, Chronic; Kidney Transplantation; Recurrence; Young Adult
Subjects: WJ Urogenital System
Depositing User: somayeh pourmorteza
Date Deposited: 05 Jan 2019 09:46
Last Modified: 05 Jan 2019 09:46
URI: http://eprints.iums.ac.ir/id/eprint/7352

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