The effects of dopaminergic drugs in the dorsal hippocampus of mice in the nicotine-induced anxiogenic-like response

Nasehi, M. and Mafi, F. and Oryan, S. and Nasri, S. and Zarrindast, M.R. (2011) The effects of dopaminergic drugs in the dorsal hippocampus of mice in the nicotine-induced anxiogenic-like response. Pharmacology Biochemistry and Behavior, 98 (3). pp. 468-473.

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Rationale: Nicotine, an active alkaloid of tobacco has an acetylcholine property that alters anxiety-like behaviors in rodents. Moreover, several investigations suggest that the mesolimbic/cortical dopamine systems to be involved in the drugs affecting anxiety. The dopaminergic modulation of acetylcholine synaptic transmission has also been also suggested by different studies. Furthermore, modulation of such behaviors in rodents may be mediated through the dorsal hippocampus. Objectives: In the present study, a possible role of the dorsal hippocampal acetylcholine receptor mechanism in nicotine's influence on anxiogenic-like responses has been investigated. Methods: During test sessions, the hole-board was used to investigate the effects of SCH23390, sulpiride, SKF38393 and quipirole on nicotine response in mice. Results: Intraperitoneal (i.p.) administration of nicotine (0.5 mg/kg) decreased the number of head dips but had no effect on other behaviors. Intra-dorsal hippocampal injections of ineffective doses of SCH23390 (SCH; 0.125 and 0.25 μg/mouse) or sulpiride (SUL; 0.5 and 0.75 μg/mouse) reversed head dips induced by nicotine but did not impact other exploratory behaviors. Furthermore, co-administration of ineffective doses of SKF38393 (SKF; 4 μg/mouse, dorsal hippocampus) or quipirole (QUI; 0.5 μg/mouse) in conjunction with an ineffective dose of nicotine (0.25 mg/kg, i.p.) decreased head dips induced by nicotine, but were otherwise ineffective. Conclusion: These results may indicate a modulatory effect for the dorsal hippocampus dopamine receptors (D 1 and D2) on an anxiogenic-like response induced by nicotine. © 2011 Elsevier Inc.

Item Type: Article
Additional Information: cited By 14
Uncontrolled Keywords: 2,3,4,5 tetrahydro 7,8 dihydroxy 1 phenyl 1h 3 benzazepine; 8 chloro 2,3,4,5 tetrahydro 3 methyl 5 phenyl 1h 3 benzazepin 7 ol hydrogen maleate; cholinergic receptor; dopamine 1 receptor; dopamine 2 receptor; dopamine receptor stimulating agent; nicotine; quipirole; sulpiride; unclassified drug, animal experiment; animal tissue; article; cognition; controlled study; dose response; drug effect; hippocampus; hole board task; male; mental task; mouse; neuromodulation; nonhuman; priority journal; treatment response, Animals; Anxiety; Behavior, Animal; Benzazepines; Dopamine Agents; Hippocampus; Male; Mice; Nicotine, Mus; Nicotiana tabacum; Rodentia
Subjects: QV Pharmacology
Depositing User: somayeh pourmorteza
Date Deposited: 05 Jan 2019 11:33
Last Modified: 05 Jan 2019 11:33

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