Synthesis, characterization and cytotoxic activity of 8-hydroxyquinoline derivatives

Jahromia, B.T. and Kharat, A.N. and Foroutannejad, S. (2011) Synthesis, characterization and cytotoxic activity of 8-hydroxyquinoline derivatives. Research Journal of Pharmaceutical, Biological and Chemical Sciences, 2 (2). pp. 61-71.

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Abstract

The cytotoxic effects of synthesized quinoline derivatives were tested against the leukemia derived Nalm6 cell lines. The preliminary cytotoxicity screening program revealed that the investigated compounds induced 50 inhibition of the cell at micromolar concentrations and thus could be considered as biologically active. The compound of 5-chloro-8-hydroxyquinolinium chloride proved superior to the remaining agents. The synthesized compounds were characterized by 1HNMR, 13CNMR and Mass spectroscopy. Moreover, the crystal structure of 5-chloro-8-hydroxyquinolinium chloride was solved which confirms the several hydrogen bonding in the solid state of this compound that stabilized crystal packing. © 2010 RJPBCS.

Item Type: Article
Additional Information: cited By 1
Uncontrolled Keywords: 2 methyl 8 hydroxyquinolium chloride; 8 hydroxyquinolinium chloride; 8 quinolinol derivative; cloxiquine; unclassified drug, antineoplastic activity; article; carbon nuclear magnetic resonance; concentration response; controlled study; crystal structure; cytotoxicity test; drug efficacy; drug screening; drug solution; drug structure; drug synthesis; human; human cell; hydrogen bond; leukemia cell line; mass spectrometry; proton nuclear magnetic resonance; solid state; structure analysis
Subjects: QV Pharmacology
Depositing User: somayeh pourmorteza
Date Deposited: 06 Jan 2019 06:22
Last Modified: 06 Jan 2019 06:22
URI: http://eprints.iums.ac.ir/id/eprint/7434

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