Anti-inflammatory effects of anti-hypertensive agents: Influence on interleukin-1β secretion by peripheral blood polymorphonuclear leukocytes from patients with essential hypertension

Nemati, F. and Rahbar-Roshandel, N. and Hosseini, F. and Mahmoudian, M. and Shafiei, M. (2011) Anti-inflammatory effects of anti-hypertensive agents: Influence on interleukin-1β secretion by peripheral blood polymorphonuclear leukocytes from patients with essential hypertension. Clinical and Experimental Hypertension, 33 (2). pp. 69-76.

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Abstract

The effects of clinically relevant concentrations of anti-hypertensive agents on lipopolysaccharide (LPS)-induced interleukin-1beta (IL-1β) secretion by polymorphonuclear leukocytes (PMNs) were investigated in vitro. Lipopolysaccharide-induced secretion of IL-1β by PMNs from 15 hypertensive and 15 normotensive subjects after incubation with losartan, captopril, amlodipine, atenolol, and hydrochlorothiazide were assessed. IL-1β secretion by PMNs markedly increased in hypertensive patients versus normotensive subjects. Losartan, captopril, and amlodipine caused a concentration-dependent attenuation of IL-1β levels in both groups. Losartan, captopril, and amlodipine demonstrated marked in vitro anti-inflammatory effects at clinically relevant serum concentrations but atenolol and hydrochlorothiazide did not. © 2011 Informa Healthcare USA, Inc.

Item Type: Article
Additional Information: cited By 10
Uncontrolled Keywords: amlodipine; antihypertensive agent; atenolol; captopril; hydrochlorothiazide; interleukin 1beta; lipopolysaccharide; losartan; amlodipine; antihypertensive agent; atenolol; autacoid; captopril; hydrochlorothiazide; interleukin 1beta; lipopolysaccharide; losartan; nonsteroid antiinflammatory agent, adult; antiinflammatory activity; article; clinical article; controlled study; cytokine release; essential hypertension; female; human; in vitro study; male; neutrophil; blood; case control study; comparative study; drug effect; hypertension; metabolism; middle aged, Adult; Amlodipine; Anti-Inflammatory Agents, Non-Steroidal; Antihypertensive Agents; Atenolol; Captopril; Case-Control Studies; Female; Humans; Hydrochlorothiazide; Hypertension; Inflammation Mediators; Interleukin-1beta; Lipopolysaccharides; Losartan; Male; Middle Aged; Neutrophils
Subjects: WG Cardiovascular System
QV Pharmacology
Depositing User: somayeh pourmorteza
Date Deposited: 06 Jan 2019 06:31
Last Modified: 06 Jan 2019 06:31
URI: http://eprints.iums.ac.ir/id/eprint/7437

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