Is the lower cyclosporine concentration at 2 hours after dosing safe in kidney transplant recipients?

Einollahi, B. and Rostami, Z. and Kalantar, E. and Lessan-Pezeshki, M. and Pourfarziani, V. and Nemati, E. (2011) Is the lower cyclosporine concentration at 2 hours after dosing safe in kidney transplant recipients? Transplantation Proceedings, 43 (2). pp. 488-490.

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Abstract

Objective: To determine the correlation between cyclosporine blood concentration at 2 hours after dosing (C2) and renal allograft function. Materials and Methods: From 2008 to 2010, 1191 kidney transplant recipients (718 male and 473 female patients) were studied. The correlation between serum creatinine concentration and C2 blood concentration was stratified as 400, 600, 800, and 1000 ng/mL. Results: The mean (SD) C2 was 620 (235) ng/mL, and serum creatinine concentration was 1.49 (0.68) mg/dL. At multivariate regression analysis, no significant correlation was observed between serum creatinine concentration and C2 blood concentrations of 600, 800, or 1000 ng/mL (P = .18, .57, and .76, respectively); however, it was associated at 400 ng/mL (P = .03). Moreover, 36.1 of 3159 samples demonstrated satisfactory renal allograft function despite low C2 blood concentration between 400 and 600 ng/mL. Conclusion: During maintenance therapy, C2 blood concentration between 400 and 600 ng/mL is effective and safe for providing prophylaxis against rejection, and can improve long-term survival by decreasing cyclosporine toxicity. © 2011 by Elsevier Inc. All rights reserved.

Item Type: Article
Additional Information: cited By 1
Uncontrolled Keywords: azathioprine; creatinine; cyclosporin A; hemoglobin; high density lipoprotein cholesterol; low density lipoprotein cholesterol; mycophenolic acid 2 morpholinoethyl ester; prednisolone; uric acid, adult; conference paper; controlled study; creatinine blood level; cytomegalovirus infection; drug blood level; drug efficacy; drug safety; female; graft dysfunction; graft recipient; human; kidney graft rejection; kidney transplantation; major clinical study; male; multiple regression; priority journal; statistical significance, Creatinine; Cyclosporine; Drug Monitoring; Female; Graft Rejection; Humans; Immunosuppressive Agents; Kidney Transplantation; Male; Multivariate Analysis; Regression Analysis; Retrospective Studies; Time Factors; Treatment Outcome
Subjects: WJ Urogenital System
Depositing User: somayeh pourmorteza
Date Deposited: 06 Jan 2019 06:54
Last Modified: 06 Jan 2019 06:54
URI: http://eprints.iums.ac.ir/id/eprint/7453

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