Cross state-dependency of learning between arachidonylcyclopropylamide (ACPA) and muscimol in the mouse dorsal hippocampus

Jafari-Sabet, M. and Karimi, A.-M. (2017) Cross state-dependency of learning between arachidonylcyclopropylamide (ACPA) and muscimol in the mouse dorsal hippocampus. Pharmacology Biochemistry and Behavior, 163. pp. 66-73.

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Abstract

The aim of the present study was to examine cross state-dependent learning between ACPA (a selective cannabinoid CB1 receptor agonist) and muscimol (a selective GABAA receptor agonist) in the step-down inhibitory avoidance learning task. The dorsal hippocampal CA1 regions of adult male NMRI mice were bilaterally cannulated, and all drugs were microinjected into the intended sites of injection. Post-training and/or pre-test administration of ACPA (1 and 2 ng/mouse) dose-dependently induced amnesia. Pre-test microinjection of the same doses of ACPA reversed the post-training ACPA-induced amnesia. This event has been named ACPA state-dependent learning (SDL). Post-training and/or pre-test microinjection of muscimol (0.05 and 0.1 μg/mouse) dose-dependently induced amnesia. Pre-test administration of the same doses of muscimol reversed the post-training muscimol-induced amnesia, suggesting muscimol SDL. The amnesia induced by post-training administration of ACPA was reversed by pre-test administration of muscimol (0.05 and 0.1 μg/mouse). Furthermore, the pre-test microinjection of muscimol (0.025 and 0.05 μg/mouse) with an ineffective dose of ACPA (0.5 ng/mouse) significantly restored memory retrieval and induced ACPA SDL. In another series of experiments, the amnesia induced by post-training administration of muscimol was reversed by pre-test administration of ACPA (1 and 2 ng/mouse). Moreover, pre-test microinjection of ACPA (0.5 and 1 ng/mouse) with an ineffective dose of muscimol (0.025 μg/mouse) significantly restored memory retrieval and induced muscimol SDL. It is important to note that pre-test intra-CA1 injection of a selective GABAA receptor antagonist, bicuculline (0.125 and 0.25 μg/mouse), 5 min before the administration of muscimol (0.1 μg/mouse) or ACPA (2 ng/mouse) dose-dependently inhibited muscimol- and ACPA-induced SDL, respectively. Pre-test intra-CA1 administration of bicuculline (0.0625, 0.125 and 0.25 μg/mouse) by itself did not affect memory retention. In conclusion, the data strongly revealed a cross SDL among ACPA and muscimol in the dorsal hippocampal CA1 regions. © 2017 Elsevier Inc.

Item Type: Article
Additional Information: cited By 1
Uncontrolled Keywords: arachidonylcyclopropylamide; cannabinoid 1 receptor agonist; muscimol; unclassified drug; arachidonic acid derivative; arachidonylcyclopropylamide; bicuculline; muscimol, adult; amnesia; animal experiment; animal model; animal tissue; Article; controlled study; dorsal hippocampus; hippocampal CA1 region; male; microinjection; mouse; nonhuman; priority journal; state dependent learning; animal; dose response; drug effect; hippocampus; learning, Animals; Arachidonic Acids; Bicuculline; Dose-Response Relationship, Drug; Hippocampus; Learning; Male; Mice; Microinjections; Muscimol
Subjects: QV Pharmacology
Depositing User: eprints admin
Date Deposited: 31 Dec 2018 10:01
Last Modified: 24 Aug 2019 06:06
URI: http://eprints.iums.ac.ir/id/eprint/7571

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