Acute pain management in emergency department, low dose ketamine versus morphine, a randomized clinical trial

Mahshidfar, B. and Mofidi, M. and Fattahi, M. and Farsi, D. and Moghadam, P.H. and Abbasi, S. and Rezai, M. (2017) Acute pain management in emergency department, low dose ketamine versus morphine, a randomized clinical trial. Anesthesiology and Pain Medicine, 7 (6).

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Abstract

Background: Ketamine, as an opium alternative, has been proposed for pain relief in the emergency department (ED). Objectives: This study was carried out to compare low dose ketamine (LDK) with morphine for pain relief in trauma patients. Methods: In this randomized double-blinded clinical trial, 300 trauma patients from the ED of 2 teaching hospitals in Tehran, Iran were enrolled and randomly divided into 2 equal groups. The 1st group received 0.2 mg/kg of ketamine while the 2nd group received 0.1 mg/kg of intravenous morphine. The pain intensity and complications were measured and compared every 15 minutes to 1 hour. Results: Fifteen minutes after drug injection in both groups, a significant reduction was found in average pain intensity compared to the initial pain (P = 0.01). At 15 minutes, no significant difference was found in both groups in regards to average pain intensity (P = 0.23). The average pain intensity at 30, 45, and 60 minutes in the group receiving morphine was lower than the ketamine group (P = 0.01, P < 0.001, P < 0.001 respectively). Two complications (drop in O2 saturation below 90 and flushing) were significantly greater in the morphine group. Conclusions: The results of this study suggest that LDK, at a dose of 0.2 mg/kg, in the earlier minutes leads to significant reduction of pain when compared to that of intravenous morphine. It also created fewer complications than morphine. © 2017, Anesthesiology and Pain Medicine.

Item Type: Article
Additional Information: cited By 0
Uncontrolled Keywords: atropine; ketamine; morphine, adult; aged; analgesia; Article; clinical outcome; controlled study; dizziness; double blind procedure; drug efficacy; emergency ward; female; hot flush; human; injury; low drug dose; major clinical study; male; minor affective disorder; musculoskeletal pain; nausea; oxygen saturation; pain intensity; patient safety; patient satisfaction; randomized controlled trial; scoring system
Subjects: WX Hospitals and Other Health Facilities
QV Pharmacology
Depositing User: eprints admin
Date Deposited: 01 Jan 2019 12:42
Last Modified: 18 Jun 2019 10:26
URI: http://eprints.iums.ac.ir/id/eprint/7581

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