Regression of nonalcoholic fatty liver disease with zinc and selenium co-supplementation after disease progression in rats

Shidfar, F. and Faghihi, A. and Amiri, H.L. and Mousavi, S.N. (2018) Regression of nonalcoholic fatty liver disease with zinc and selenium co-supplementation after disease progression in rats. Iranian Journal of Medical Sciences, 43 (1). pp. 26-31.

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Abstract

Background: Studies have shown that zinc and selenium deficiency is common in nonalcoholic fatty liver disease (NAFLD). However, the effects of zinc and selenium co-supplementation before and/or after disease progression on NAFLD are not clear enough. The aim of this study was to compare the effects of zinc and selenium co-supplementation before and/or after disease progression on NAFLD prognosis. Methods: Forty male Sprague�Dawley rats (197±4 g) were randomly assigned to 4 dietary groups: normal-fat diet (NFD; receiving 9 of calories as fat), high-fat diet (HFD; receiving 82 of calories as fat), supplementation before disease progression (S+HFD), and supplementation after disease progression (HFD+S). The diets were implemented over a 20-week period in all the groups. Biochemical and histologic parameters were compared between the 4 groups, and betweengroup comparisons were also carried out. Results: There were significant differences in the average food dietary intake (P<0.001), weight (P<0.001), fasting blood sugar (P=0.005), triglyceride (P<0.001), total cholesterol (P<0.001), low-density lipoprotein cholesterol (P=0.002), high-density lipoprotein cholesterol (P=0.001), alanine aminotransferase (P<0.001), and aspartate aminotransferase (P<0.001) between the 4 dietary groups. Serum triglyceride and total cholesterol were significantly lower in the HFD+S Group than in the S+HFD Group (P<0.001 and P=0.003, respectively). Fat accumulation was significantly reduced in the HFD+S Group (P<0.001). Conclusion: Zinc and selenium co-supplementation after disease progression improved biochemical and histologic parameters in an experimental model of NAFLD. © 2018, Shiraz University of Medical Sciences. All rights reserved.

Item Type: Article
Additional Information: cited By 0
Subjects: WI Digestive System
QV Pharmacology
Depositing User: eprints admin
Date Deposited: 05 Aug 2018 03:21
Last Modified: 21 Sep 2019 05:15
URI: http://eprints.iums.ac.ir/id/eprint/864

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