The protective role of carnosic acid against beta-amyloid toxicity in rats

Rasoolijazi, H. and Azad, N. and Joghataei, M.T. and Kerdari, M. and Nikbakht, F. and Soleimani, M. (2013) The protective role of carnosic acid against beta-amyloid toxicity in rats. The Scientific World Journal, 2013.

[img] Text
917082.pdf

Download (2MB)
Official URL: https://www.scopus.com/inward/record.uri?eid=2-s2....

Abstract

Oxidative stress is one of the pathological mechanisms responsible for the beta- amyloid cascade associated with Alzheimer's disease (AD). Previous studies have demonstrated the role of carnosic acid (CA), an effective antioxidant, in combating oxidative stress. A progressive cognitive decline is one of the hallmarks of AD. Thus, we attempted to determine whether the administration of CA protects against memory deficit caused by beta-amyloid toxicity in rats. Beta-amyloid (1-40) was injected by stereotaxic surgery into the Ca1 region of the hippocampus of rats in the Amyloid beta (Aβ) groups. CA was delivered intraperitoneally, before and after surgery in animals in the CA groups. Passive avoidance learning and spontaneous alternation behavior were evaluated using the shuttle box and the Y-maze, respectively. The degenerating hippocampal neurons were detected by fluoro-jade b staining. We observed that beta-amyloid (1-40) can induce neurodegeneration in the Ca1 region of the hippocampus by using fluoro-jade b staining. Also, the behavioral tests revealed that CA may recover the passive avoidance learning and spontaneous alternation behavior scores in the Aβ + CA group, in comparison with the Aβ group. We found that CA may ameliorate the spatial and learning memory deficits induced by the toxicity of beta-amyloid in the rat hippocampus. © 2013 H. Rasoolijazi et al.

Item Type: Article
Additional Information: cited By 17
Uncontrolled Keywords: abietane derivative; amyloid beta protein; plant extract; salvin, animal; article; avoidance behavior; male; maze test; rat; Wistar rat, Amyloid beta-Peptides; Animals; Avoidance Learning; Diterpenes, Abietane; Male; Maze Learning; Plant Extracts; Rats; Rats, Wistar
Subjects: QV Pharmacology
Depositing User: somayeh pourmorteza
Date Deposited: 29 Sep 2019 06:44
Last Modified: 29 Sep 2019 06:44
URI: http://eprints.iums.ac.ir/id/eprint/9527

Actions (login required)

View Item View Item