Effects of pinus eldarica Medw. nut extract on blood glucose and cholesterol levels in hypercholesterolemic alloxan-induced diabetic rats

Huseini, F.H. and Mehrzadi, S. and Ghaznavi, H. and Tajallizadehkhoob, Y. and Fakhrzadeh, H. (2013) Effects of pinus eldarica Medw. nut extract on blood glucose and cholesterol levels in hypercholesterolemic alloxan-induced diabetic rats. Journal of Medicinal Plants, 12 (45). pp. 68-74.

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Abstract

Background: Diabetes mellitus type 2 with dyslipidemia is a common disease. Previous studies suggest that chemical constituent present in pinus eldarica (P. eldarica) nut posesess antioxidant properties and positively affect glucose metabolism. However blood glucose and cholesterol lowering effects of P. eldarica nut have not been studied so far. Objective: The present study was undertaken to explore the possiblility of anti-hyperglycemic and anti-hypercholesterolemic effects of the P. eldarica nut extract in hypercholesterolemic diabetic rats. Methods: Sixty male wistar rats six months of age from central animal house of the institute of medicinal plants were selected. 10 rats were kept as normal group and diabetes was induced in the remaining rats by intraperitonial injection of 120 mg/kg aloxan monohydrate. After one week the diabetic rats with fasting blood glucose between 180 to 250 mg/kg were assigned to 5 groups of 10 rats each and were fed on hypercholesterolemic diet. One group was kept as control group (untreated diabetic rats) and P. eldarica nut extract in doses of 50, 100, 200 and 400 mg/kg was gavaged daily to the remaining rats. After one month, the fasting blood glucose, cholesterol and triglyceride levels were determined in all groups. Results: The results indicate that fasting blood glucose in 200 and 400 mg/kg P. eldarica nut extract treated groups significantly decreased (P=0.000 and P=0.000) and fasting blood cholesterol and triglyceride levels did not change significantly compared with control group. Conclusion: P. eldarica nut extract lowers blood glucose level withought affecting blood cholesterol and triglyceride levels in hypercholesterolemic diabetic rats.

Item Type: Article
Additional Information: cited By 7
Uncontrolled Keywords: alloxan; antidiabetic agent; cholesterol; glucose; hypocholesterolemic agent; Pinus eldarica nut extract; plant extract; triacylglycerol; unclassified drug, animal experiment; animal model; antidiabetic activity; article; cholesterol blood level; controlled study; drug effect; glucose blood level; hypercholesterolemia; male; non insulin dependent diabetes mellitus; nonhuman; pine; Pinus eldarica; rat; triacylglycerol blood level
Subjects: QU Biochemistry. Cell Biology and Genetics
QV Pharmacology
Depositing User: somayeh pourmorteza
Date Deposited: 29 May 2019 13:01
Last Modified: 29 May 2019 13:01
URI: http://eprints.iums.ac.ir/id/eprint/9541

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