Effect of low-dose Dopamine on lactate level in patients undergoing coronary bypass surgery

Azarasa, M. and Faritous, Z. and Jalali, A. and Dehaki, M.G. and Massoumi, G. (2013) Effect of low-dose Dopamine on lactate level in patients undergoing coronary bypass surgery. Iranian Heart Journal, 14 (2). pp. 13-18.

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Background: The aim of this study was to study the effect of low-dose Dopamine on the blood lactate levels as a sign of visceral perfusion in coronary artery bypass graft surgery (CABG) patients. Methods: In a double-blinded, randomized clinical trial, 100 adult patients - who were candidated for elective isolated CABG surgery - were divided equally into two groups of low-dose Dopamine group (2 μg / kg / min) and control group (n=50 in each). Lactate levels, arterial blood gas analyses, blood pressure, and heart rate were recorded intraoperatively at four time points: before the induction of anesthesia; 15 minutes after the beginning of cardiopulmonary bypass (CPB); during CPB at rewarming to 34°C; and 15 minutes after separation from CPB. These biochemical and hemodynamic parameters were compared in these four time points between the two study groups. Results: Arterial blood gas and hemodynamic parameters were similar between the two groups during surgery (p values > 0.05). There were no significant differences between the lactate levels in the Dopamine and control groups at the beginning of CPB (3.1 ± 2.5 vs. 2.6 ± 2.0 mg/dl; p value = 0.453), at the time of rewarming (3.1 ± 2.5 vs. 2.6 ± 2.0 mg/dl; p value = 0.510), and after CPB (3.1 ± 2.5 vs. 2.6 ± 2.0 mg/dl; p value = 0.551) - respectively. Conclusions: The use of low-dose Dopamine did not decrease lactate levels in our CABG patients using CPB.

Item Type: Article
Additional Information: cited By 0
Uncontrolled Keywords: bicarbonate; dopamine; lactic acid; protamine sulfate, adult; artery catheter; article; blood gas analysis; controlled study; coronary artery bypass surgery; diastolic blood pressure; double blind procedure; female; heart left ventricle ejection fraction; heart rate; hematocrit; human; lactate blood level; low drug dose; major clinical study; male; randomized controlled trial; risk factor; systolic blood pressure; warming
Subjects: WO Surgery
WG Cardiovascular System
QV Pharmacology
Depositing User: somayeh pourmorteza
Date Deposited: 26 May 2019 06:43
Last Modified: 26 May 2019 06:43
URI: http://eprints.iums.ac.ir/id/eprint/9621

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