Electrocardiographic manifestations in acute methanol poisoning cannot predict mortality

Sanaei-Zadeh, H. and Emamhadi, M. and Farajidana, H. and Zamani, N. and Amirfarhangi, A. (2013) Electrocardiographic manifestations in acute methanol poisoning cannot predict mortality. Arhiv za Higijenu Rada i Toksikologiju, 64 (2). pp. 265-271.

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[Archives of Industrial Hygiene and Toxicology] Electrocardiographic Manifestations in Acute Methanol Poisoning Cannot Predict Mortality.pdf

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Abstract

The aim of this retrospective observational case series was to determine electrocardiographic (ECG) manifestations in patients poisoned with methanol and see whether they could predict mortality. We also wanted to see whether there was an association between ECG changes and time elapsed between ingestion and treatment, age, sex, seizure, coma (Glasgow Coma Scale �8), arterial blood gas (ABG) parameters, and serum potassium levels on hospital admission. The study included 42 patients aged 31.14±12.5 years. Twenty-five survived and 17 died. Almost all patients had one or more abnormal ECG findings, including heart rate, rhythm, and conduction abnormalities. However, we found no significant difference between survivors and non-survivors. QTc interval did not correlate with time elapsed between ingestion and treatment, age, sex, seizure and coma, HCO3 -, or serum potassium level. Similarly, T waves showed no correlation with serum potassium. ECG abnormalities did not correlate with coma or seizure. Even though cardiotoxicity in methanol poisoning is high, none of the ECG abnormalities found in our study predicted mortality. This however does not rule out the need to routinely run ECG for cardiotoxicity in every single patient poisoned by methanol.

Item Type: Article
Additional Information: cited By 1
Uncontrolled Keywords: alcohol; bicarbonate; folic acid; folinic acid; methanol; potassium, adolescent; adult; aged; arterial gas; cardiotoxicity; clinical article; coma; conference paper; controlled study; ECG abnormality; electrocardiography; female; Glasgow coma scale; heart atrium fibrillation; heart muscle conduction disturbance; heart rate and rhythm; heart ventricle extrasystole; hemodialysis; human; male; methanol poisoning; mortality; observational study; potassium blood level; PR interval; predictive value; QRS complex; QT interval; retrospective study; seizure; ST segment depression; supraventricular premature beat; survival; survivor; T wave
Subjects: WG Cardiovascular System
QV Pharmacology
Depositing User: somayeh pourmorteza
Date Deposited: 14 May 2019 09:51
Last Modified: 14 May 2019 09:51
URI: http://eprints.iums.ac.ir/id/eprint/9699

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