Vitamin D status and its association with antioxidant profiles in diabetic patients: A cross-sectional study in Iran

Saedisomeolia, A. and Taheri, E. and Djalali, M. and Djazayeri, A. and Qorbani, M. and Rajab, A. and Larijani, B. (2013) Vitamin D status and its association with antioxidant profiles in diabetic patients: A cross-sectional study in Iran. Indian Journal of Medical Sciences, 67 (1). pp. 29-37.

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Abstract

BACKGROUND AND OBJECTIVES: There are increasing evidences about the relationship between vitamin D status and the control of diabetes. Several studies showed that vitamin D has an antioxidant property. In this study, we aimed to determine the relationship between serum levels of 25-hydroxy vitamin D (25-OH-D) and glycemic, antioxidant profile in diabetes compared to healthy groups. MATERIALS AND METHODS: This cross-sectional study was conducted in 100 patients with type 2 diabetes mellitus (T2DM) and 100 healthy controls. Fasting serum levels of 25-OH-D, calcium, phosphorous, parathyroid hormone, glucose, HbA1C, insulin, homeostasis model assessment of insulin resistance index, total antioxidant capacity (TAC), activities of superoxide dismutase (SOD), glutathione reductase (GR), and glutathione peroxidase (GSH-PX) were measured. RESULTS: Eighty-two percent of type 2 diabetic patients and 75 of healthy subjects were suffering from vitamin D deficiency or insufficiency. The activities of GR and GSH-PX were higher in diabetic patients compared to control. There was a negative relationship between 25-OH-D and activity of GR, GSH-PX. Also, 25-OH-D had a positive association with activity of SOD in diabetic patients. In the control group, 25-OH-D had an inverse relationship with SOD, GSH-PX, and positively with GR activities. INTERPRETATION AND CONCLUSIONS: Vitamin D deficiency has a high prevalence among Iranian adult population with and without type 2 diabetes. Our results showed that vitamin D may have a beneficial effect on the control of glycemic profiles and oxidative stress in T2DM patients.

Item Type: Article
Additional Information: cited By 15
Uncontrolled Keywords: calcifediol; calcium; glucose; glutathione peroxidase; glutathione reductase; hemoglobin A1c; insulin; parathyroid hormone; phosphorus; superoxide dismutase, adult; antioxidant activity; article; calcium blood level; controlled study; cross-sectional study; diabetes mellitus; diabetic patient; diet restriction; enzyme activity; female; glucose blood level; hemoglobin blood level; human; insulin blood level; insulin resistance; Iran; major clinical study; male; parathyroid hormone blood level; phosphate blood level; vitamin blood level; vitamin D deficiency, Adult; Aged; Aged, 80 and over; Antioxidants; Case-Control Studies; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Female; Glutathione Peroxidase; Glutathione Reductase; Humans; Iran; Male; Middle Aged; Oxidative Stress; Superoxide Dismutase; Vitamin D; Vitamin D Deficiency; Young Adult
Subjects: QV Pharmacology
Depositing User: somayeh pourmorteza
Date Deposited: 28 Jan 2019 07:09
Last Modified: 28 Jan 2019 07:09
URI: http://eprints.iums.ac.ir/id/eprint/9785

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