Protective effects of manganese on the testis structure and sperm parameters of formalin-treated mice

Tajaddini, S. and Ebrahimi, S. and Shirinbayan, P. and Bakhtiyari, M. and Behnam, B. and Joghataei, M.T. and Koruji, M. (2013) Protective effects of manganese on the testis structure and sperm parameters of formalin-treated mice. Journal of Isfahan Medical School, 31 (243). pp. 1018-1032.

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Abstract

Background: Formaldehyde, as a ubiquitous environmental pollutant, is extensively used in industrial and hospitals settings. The aim of this study was to investigate the protective role of manganese on testis structure and sperm parameters in adult mice exposed to formaldehyde (FA). Methods: After dose optimizing for FA and manganese chloride, twenty adult male NMRI mice were selected and randomly divided into four groups: (i) control, (ii) sham, (iii) FA-exposed, and (iv) FA and manganese chloride exposed. The FA-exposed groups received 10 mg/ kg FA daily for 14 days, and 5 mg/kg manganese chloride was just injected intraperitoneally on 2nd week. Mice were sacrificed, and spermatozoa were collected from the caudal of the right epididymis and analyzed for count, motility, morphology and viability. The other testicular tissues were weighed and prepared for histological examination upon removal. Seminiferous tubules, lumen diameters and epithelium thickness were also measured. Findings: The findings revealed that FA significantly reduced the testicular weight, sperm count, motility, viability and normal morphology compared with control group (P � 0.05). In addition, seminiferous tubules atrophied and seminiferous epithelial cells disintegrated in the FA group in comparison with the control group (P � 0.05). However, manganese improved the testicular structure and sperm parameters in FA-treated mice testes (P � 0.05). Conclusion: According to the results, manganese has protective effects on mice epididymal sperm parameters and testis structure treated with FA.

Item Type: Article
Additional Information: cited By 4
Subjects: WJ Urogenital System
QV Pharmacology
Depositing User: somayeh pourmorteza
Date Deposited: 06 Jan 2019 08:48
Last Modified: 06 Jan 2019 08:48
URI: http://eprints.iums.ac.ir/id/eprint/9811

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