Does L-carnitine improve endothelial function in hemodialysis patients?

Sabri, M.R. and Fahimi, F. and Hajialiasgar, S. and Etminan, A. and Nazemi, S. and Salehi, F. (2012) Does L-carnitine improve endothelial function in hemodialysis patients? Journal of Research in Medical Sciences, 17 (5). pp. 417-421.

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Abstract

Background: Atherosclerosis is the leading cause of death in hemodialysis patients. These patients are also very prone to Lcarnitine deficiency due to kidney disease. In this clinical trial, we investigated the effect of oral L-carnitine on endothelial function of these patients. Materials ans Methods: We studied 31 adult chronic hemodialysis patients in our center and divided them into two groups. The first group (n = 20) received 1500 mg/dialysis interval (every other day) oral L-carnitine. The control group (n = 11) received placebo for one month. Ultrasonographic measurements of flow mediated dilation and carotid intima-media thickness were performed before and after one month of L-carnitine and placebo therapy. Results: This study showed that after one month of Lcarnitine or placebo therapy there was no significant improvement in flow mediated dilation (p = 0.80 and p = 0.59, respectively) or decrease in carotid intima-media thickness (p = 0.12 and p = 0.50, respectively). Conclusions: Our study revealed that one month of oral L-carnitine therapy did not improve endothelial function in hemodialysis patients. Long-term studies with large sample size using intravenous form and higher doses of the drug are required to clarify the questionable role of L-carnitine in hemodialysis patients.

Item Type: Article
Additional Information: cited By 4
Uncontrolled Keywords: carnitine; dipeptidyl carboxypeptidase inhibitor; hemoglobin A1c; placebo, adult; arterial wall thickness; article; atherosclerosis; brachial artery; chronic kidney failure; clinical article; controlled study; diabetes mellitus; double blind procedure; drug withdrawal; echography; endothelial dysfunction; endothelium cell; female; hemodialysis patient; human; male; multicenter study; nausea and vomiting; randomized controlled trial; vasodilatation
Subjects: WJ Urogenital System
QV Pharmacology
Divisions: School of Rehabilitation Sciences
Depositing User: parto mrs bakhtminoo
Date Deposited: 06 Jan 2019 10:42
Last Modified: 06 Jan 2019 10:42
URI: http://eprints.iums.ac.ir/id/eprint/9882

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