Comparison of metronidazole and ceftizoxime in prophylaxis of post-hysterectomy infections

Rahimi-Moghaddam, P. and Zahedi, M. and Eftekhar, Z. (2007) Comparison of metronidazole and ceftizoxime in prophylaxis of post-hysterectomy infections. Iranian Journal of Pharmacology and Therapeutics, 6 (2). pp. 155-157.

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Ceftizoxime is a common agent used in prophylaxis of infections after abdominal hysterectomy. Metronidazole could be used instead of ceftizoxime for this matter. To compare these two drugs, in a randomized clinical trial, 30 patients received metronidazole suppositories (1g) and 33 patients received intravenous ceftizoxime (1g) before surgery. There were not any significant demographic (age, weight, parity, hospitalization duration, pre-operation hemoglobin) differences between two groups. Also, the incision type and post-operation bleeding were the same in two groups. The complications after abdominal hysterectomy such as febrile morbidity, urinary tract infections and wound infections were not significantly different between two treatment groups. These results indicate that a single dose metronidazole has the same effect as ceftizoxime in infection prophylaxis of post-hysterectomy infection. Copyright © 2006 by Razi Institute for Drug Research (RIDR).

Item Type: Article
Additional Information: cited By 1
Uncontrolled Keywords: ceftizoxime; hemoglobin; metronidazole, abdominal hysterectomy; adult; article; bleeding; clinical trial; controlled clinical trial; controlled study; demography; drug efficacy; drug safety; female; fever; hemoglobin blood level; hospitalization; human; length of stay; major clinical study; parity; postoperative infection; randomized controlled trial; single drug dose; suppository; urinary tract infection; wound infection
Subjects: WP Gynecology
QV Pharmacology
Divisions: School of Rehabilitation Sciences
Depositing User: parto mrs bakhtminoo
Date Deposited: 26 Jan 2019 11:11
Last Modified: 26 Jan 2019 11:11

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