Prediction of kidney survival in children with primary focal segmental glomerulosclerosis (a two-center study)

Gheissari, A. and Otookesh, H. and Madani, A. (2007) Prediction of kidney survival in children with primary focal segmental glomerulosclerosis (a two-center study). Journal of Research in Medical Sciences, 12 (3). pp. 107-111.

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Background: Focal segmental glomerulosclerosis (FSGS) is one of the most common glomerulopathies in children leading to end stage renal disease (ESRD). Different values of median renal survival have been reported among different ethnicities and races. Many factors are assumed to be responsible for ESRD in these patients. In this study, we tried to determine median renal survival (MRS) and also some clinical and histopathological features predisposing FSGS patients to ESRD in two referral hospitals in Tehran. Methods: The study involved 103 FSGS patients (61 males and 42 females) with a mean age of 7.08 ± 0.68 years. The diagnosis was made based on kidney biopsies. All kidney biopsies were studied by light and immunofluorescent microscopes. Ocular grids (counting squares) were used as the standard method to calculate the percentage of cortical interstitial fibrosis (CIF). The percentage of glomerular sclerosis was presented as renal injury score. Glomerular filtration rate (GFR)�50 ml/min was considered as renal death or the end point. Patients were followed for 1 to 15 years, until occurrence of renal death. Results: The MRS was 9.04 ± 1.8 yrs. The renal survival reached 72, 47 and 17 after 5, 10 and 15 years, respectively. Univariate analysis showed significant reverse correlation (P<0.05) between renal survival and the following variables: hypertension, anemia, GFR at the time of first admission and also renal injury score >50, peritubular fibrosis, periglomerular fibrosis, tubular atrophy and CIF�20. However, multivariate analysis revealed only a reverse correlation between renal survival with CIF�20 and also hypertension (P<0.0001 and P<0.05, respectively). Conclusions: In our patients, FSGS showed a rapid course towards ESRD compared with patients of western countries. Perhaps some ethnic and genetic factors such as angiotensin converting enzyme genotypes (ACE-DD) can be considered as a cause of this rapid progression. Also, we carried this study only on children and adolescents which might change the MRS results.

Item Type: Article
Additional Information: cited By 3
Uncontrolled Keywords: dipeptidyl carboxypeptidase, adolescent; anemia; article; child; clinical feature; controlled study; disease course; disease predisposition; ethnicity; female; focal glomerulosclerosis; glomerulosclerosis; glomerulus filtration rate; heredity; histopathology; human; human tissue; hypertension; immunofluorescence microscopy; Iran; kidney biopsy; kidney failure; kidney fibrosis; major clinical study; male; scoring system; survival rate
Subjects: WJ Urogenital System
WS Pediatrics
Divisions: School of Rehabilitation Sciences
Depositing User: parto mrs bakhtminoo
Date Deposited: 26 Jan 2019 11:12
Last Modified: 26 Jan 2019 11:12

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