Risk Factors for Early Dialysis Dependency in Autosomal Recessive Polycystic Kidney Disease

Burgmaier, K. and Kunzmann, K. and Ariceta, G. and Bergmann, C. and Buescher, A.K. and Burgmaier, M. and Dursun, I. and Duzova, A. and Eid, L. and Erger, F. and Feldkoetter, M. and Galiano, M. and Ge�ner, M. and Goebel, H. and Gokce, I. and Haffner, D. and Hooman, N. and Hoppe, B. and Jankauskiene, A. and Klaus, G. and König, J. and Litwin, M. and Massella, L. and Mekahli, D. and Melek, E. and Mir, S. and Pape, L. and Prikhodina, L. and Ranchin, B. and Schild, R. and Seeman, T. and Sever, L. and Shroff, R. and Soliman, N.A. and Stabouli, S. and Stanczyk, M. and Tabel, Y. and Taranta-Janusz, K. and Testa, S. and Thumfart, J. and Topaloglu, R. and Weber, L.T. and Wicher, D. and Wühl, E. and Wygoda, S. and Yilmaz, A. and Zachwieja, K. and Zagozdzon, I. and Zerres, K. and Ranguelov, N. and Godefroid, N. and Collard, L. and Lombet, J. and Maquet, J. and Schalk, G. and Querfeld, U. and Beck, B.B. and Benzing, T. and Buettner, R. and Grundmann, F. and Kurschat, C. and Benz, K. and Tzschoppe, A. and Buchholz, B. and Buescher, R. and Häffner, K. and Pohl, M. and Gross, O. and Krügel, J. and Stock, J. and Patzer, L. and Oh, J. and Bernhardt, W. and Doyon, A. and Vinke, T. and Sander, A. and Henn, M. and Derichs, U. and Beetz, R. and Jeck, N. and Lange-Sperandio, B. and Ponsel, S. and Kusser, F. and Uetz, B. and Benz, M. and Schmidt, S. and Huppertz-Kessler, C. and Kranz, B. and Titieni, A. and Wurm, D. and Leichter, H.E. and Bald, M. and Billing, H. and Nabhan, M.M. and Lara, L.E. and Papachristou, F. and Emma, F. and Cerkauskiene, R. and Azukaitis, K. and Wasilewska, A. and Balasz-Chmielewska, I. and Miklaszewska, M. and Tkaczyk, M. and Sikora, P. and Zaniew, M. and Niemirska, A. and Antoniewicz, J. and Lesiak, J. and Afonso, A.C. and Teixeira, A. and Milosevski-Lomic, G. and Paripovi�, D. and Peco-Antic, A. and Papizh, S. and Bayazit, A.K. and Anarat, A. and Soylu, A. and Kavukcu, S. and Candan, C. and Caliskan, S. and Canpolat, N. and Emre, S. and Alpay, H. and Akinci, N. and Conkar, S. and Poyrazoglu, H.M. and Dusunsel, R. and Dötsch, J. and Schaefer, F. and Liebau, M.C. and Group, ESCAPE Study and Group, GPN Study and ARegPKD consortium, (2018) Risk Factors for Early Dialysis Dependency in Autosomal Recessive Polycystic Kidney Disease. Journal of Pediatrics.

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Objective: To identify prenatal, perinatal, and postnatal risk factors for dialysis within the first year of life in children with autosomal recessive polycystic kidney disease (ARPKD) as a basis for parental counseling after prenatal and perinatal diagnosis. Study design: A dataset comprising 385 patients from the ARegPKD international registry study was analyzed for potential risk markers for dialysis during the first year of life. Results: Thirty-six out of 385 children (9.4) commenced dialysis in the first year of life. According to multivariable Cox regression analysis, the presence of oligohydramnios or anhydramnios, prenatal kidney enlargement, a low Apgar score, and the need for postnatal breathing support were independently associated with an increased hazard ratio for requiring dialysis within the first year of life. The increased risk associated with Apgar score and perinatal assisted breathing was time-dependent and vanished after 5 and 8 months of life, respectively. The predicted probabilities for early dialysis varied from 1.5 (95 CI, 0.5-4.1) for patients with ARPKD with no prenatal sonographic abnormalities to 32.3 (95 CI, 22.2-44.5) in cases of documented oligohydramnios or anhydramnios, renal cysts, and enlarged kidneys. Conclusions: This study, which identified risk factors associated with onset of dialysis in ARPKD in the first year of life, may be helpful in prenatal parental counseling in cases of suspected ARPKD. © 2018 Elsevier Inc.

Item Type: Article
Additional Information: cited By 0; Article in Press
Depositing User: eprints admin
Date Deposited: 01 Jul 2018 03:52
Last Modified: 03 Oct 2018 10:05
URI: http://eprints.iums.ac.ir/id/eprint/1017

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