The effect of preoperative aspirin use on postoperative bleeding and perioperative myocardial infarction in patients undergoing coronary artery bypass surgery

Ghaffarinejad, M.H. and Fazelifar, A.F. and Shirvani, S.M. and Asdaghpoor, E. and Fazeli, F. and Bonakdar, H.R. and Noohi, F. (2007) The effect of preoperative aspirin use on postoperative bleeding and perioperative myocardial infarction in patients undergoing coronary artery bypass surgery. Cardiology Journal, 14 (5). pp. 453-457.


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Background: We tried to evaluate the clinical outcomes (mortality, postoperative bleeding and perioperative myocardial infarction) of patients who underwent first elective coronary artery bypass grafting and received aspirin during the preoperative period. Methods: The study was a prospective, randomized and single-blinded clinical trial. Two hundred patients were included and divided into two groups. One group received aspirin 80-160 mg, while in the other aspirin was stopped at least seven days before surgery. The primary end-points of the study were in-hospital mortality and hemorrhage-related complications (postoperative blood loss in the intensive care unit, re-exploration for bleeding and red blood cell and non-red blood cell requirements). The secondary end-point was perioperative myocardial infarction. Results: There were no differences in patient characteristics between the aspirin users and non-aspirin users. We found a significant difference between postoperative blood loss (608 ± ± 359.7 ml vs. 483 ± 251.5 ml, p = 0.005) and red blood cell product requirements (1.32 2+ ± 0.97 unit packed cell vs. 0.94 ± 1.02 unit packed cell, p = 0.008). There was no significant difference between the two groups regarding platelet requirement and the rate of in-hospital mortality and re-exploration for bleeding. Similarly, we found no significant difference in the incidence of definite and probable perioperative myocardial infarction (p = 0.24 and p = 0.56 respectively) or in-hospital mortality between the two groups. Conclusion: Preoperative aspirin administration increased postoperative bleeding and red blood cell requirements with no effect on mortality, re-exploration rate and perioperative myocardial infarction. We recommend withdrawal of aspirin seven days prior to surgery. Copyright © 2007 Via Medica.

Item Type: Article
Additional Information: cited By 17
Uncontrolled Keywords: acetylsalicylic acid; aprotinin, adult; aged; article; clinical trial; controlled clinical trial; controlled study; coronary artery bypass surgery; drug efficacy; drug response; drug withdrawal; elective surgery; erythrocyte; erythrocyte concentrate; erythrocyte transfusion; female; heart infarction; human; incidence; major clinical study; male; mortality; outcome assessment; postoperative hemorrhage; preoperative care; randomized controlled trial; single blind procedure; single drug dose
Subjects: WG Cardiovascular System
QV Pharmacology
Divisions: School of Rehabilitation Sciences
Depositing User: parto mrs bakhtminoo
Date Deposited: 26 Feb 2019 08:59
Last Modified: 26 Feb 2019 08:59

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