Norouzi, M. and Ramezani, F. and Khedive, A. and Karimzadeh, H. and Alavian, S.M. and Malekzadeh, R. and Montazeri, G. and Nejatizadeh, A. and Ziai, M. and Abedi, F. and Ataei, B. and Yaran, M. and Sayad, B. and Somi, M.H. and Sarizade, G. and Sanei-Moghaddam, I. and Mansour-Ghanaei, F. and Rafatpanah, H. and Pourhosseingholi, M.A. and Keyvani, H. and Shahmoradi, S. and Saberifiroozi, M. and Sadeghi, M. and Geravand, B. and Daram, M. and Mahabadi, M. and Goodarzi, Z. and Rezaee, R. and Poortahmasebi, V. and Fakhari, Z. and Jazayeri, S.M. (2014) Hepatitis B virus genotype D is the only genotype circulating in Iranian chronic carriers, the unique pattern of genotypic homogeneity. Journal of Gastroenterology and Hepatology Research, 3 (9). pp. 1238-1243.
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Hepatitis B virus genotype D is the only genotype circulating in Iranian chronic carriers, the unique pattern of genotypic homogeneity.pdf Download (6MB) | Preview |
Abstract
Aim: To characterize the hepatitis B virus surface protein genotypes and sequence variations among HBsAg positive chronic Iranian patients from different ethnic groups. Method: The surface genes from 312 patients were amplified and directly sequenced. Results: All strains (100) belonged to genotype D and subtypes ayw2. The average nucleotide mutation frequency was 0.91 (dN/dS < 1.0), indicated negative selection. There was no significant correlation between HBV DNA and ALT levels and the occurrence of amino acid substitutions. However, in terms of HBeAg/Anti-HBe status, the association between both groups for silent nucleotide mutation was strong, indicating selection bias on missense mutations. A higher number of amino acid mutations was found in anti-HBe positive versus HBeAg positive patients.Conclusion: The uniqueness pattern of HBV genetics hemogeniety together with the low mutational frequency indicated that HBV has introduced to Iran recently and isolation of people in the absence of intermixing with other genotypes led to a homologous pattern. © 2014 ACT.
| Item Type: | Article |
|---|---|
| Additional Information: | cited By 5 |
| Uncontrolled Keywords: | alanine aminotransferase; amino acid; hepatitis B surface antigen; hepatitis B(e) antibody; hepatitis B(e) antigen; membrane protein; nucleotide; virus DNA, adult; amino acid substitution; Article; DNA sequence; ethnic group; female; Hepatitis B virus genotype D; heterozygote; human; Iranian (citizen); major clinical study; male; missense mutation; mutation rate; nucleotide sequence; phylogeny; selection bias; unindexed sequence; virus load |
| Subjects: | WC Communicable Diseases |
| Depositing User: | Ms Roya Vesal Azad |
| Date Deposited: | 26 Feb 2019 10:30 |
| Last Modified: | 26 Feb 2019 10:30 |
| URI: | http://eprints.iums.ac.ir/id/eprint/11831 |
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