Mirzaee, R. and Allameh, A. and Mortazavi, S.B. and Khavanin, A. and Kazemnejad, A. and Akbary, M. (2007) Assessment of outer hair cell function and blood antioxidant status of rabbits exposed to noise and metal welding fumes. Auris Nasus Larynx, 34 (2). pp. 147-154.
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Abstract
Objectives: To investigate the interaction between welding fumes and noise in causation of hearing impairment. Methods: Groups of rabbits (n = 6) were exposed to noise, welding fumes or combination of both prior to Distortion Product Otoacoustic-Emissions (DPOAEs) analysis. The function of outer hair cells (OHCs) was examined by DPOAE assessment over a broad range of frequencies. Variations in DPOAE amplitude were compared between control (n = 6) and exposed (n = 18) groups. Results: The DPOAEs levels measured at different frequencies (1379-6299 Hz) were found to decrease significantly (P < 0.05) in rabbits exposed to 110 dB sound pressure level (SPL) broadband noise (8 h/day, 12 days). In rabbits, exposed to carbon-steel welding fumes alone (157 mg/m3), the threshold shift was limited to the high frequencies (2759-6299 Hz), whereas, mixed exposure to noise and fumes resulted in reduction of DPOAEs at all the frequencies. Changes in DPOAEs were associated with increased susceptibility of erythrocytes to oxidation (P < 0.05). Exposure to noise or fumes alone or simultaneously, suppressed total antioxidant ability of plasma as measured by ferric reducing ability of plasma (FRAP). Noise alone or in combination with fumes resulted in depletion of blood glutathione (GSH). Despite suppression of FRAP in the exposed groups, GSH was found to remain unchanged due to welding fumes suggesting that antioxidants other than GSH are affected by toxicants present in metal welding fumes. Conclusion: Exposure to very high levels of welding fumes can increase noise-related effects on OHC function by extending hearing threshold shift to wide band frequencies. © 2006 Elsevier Ireland Ltd. All rights reserved.
| Item Type: | Article |
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| Additional Information: | cited By 7 |
| Uncontrolled Keywords: | antioxidant; carbon; glutathione; steel, animal cell; animal experiment; antioxidant activity; article; auditory threshold shift; blood; cell function; controlled study; distortion product otoacoustic emission; erythrocyte; hair cell; hearing impairment; industrial noise; male; nonhuman; oxidation; protein blood level; rabbit; sound pressure; statistical significance; welding fume, Air Pollutants, Occupational; Animals; Antioxidants; Glutathione; Hair Cells, Outer; Hearing Loss, Noise-Induced; Lipid Peroxidation; Male; Noise; Otoacoustic Emissions, Spontaneous; Pitch Perception; Rabbits; Threshold Limit Values; Welding |
| Subjects: | WV Otolaryngology |
| Divisions: | School of Rehabilitation Sciences |
| Depositing User: | parto mrs bakhtminoo |
| Date Deposited: | 26 Feb 2019 10:52 |
| Last Modified: | 26 Feb 2019 10:52 |
| URI: | http://eprints.iums.ac.ir/id/eprint/11865 |
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