Haghjoo, M. and Bagherzadeh, A. and Fazelifar, A.F. and Haghighi, Z.O. and Esmaielzadeh, M. and Alizadeh, A. and Emkanjoo, Z. and Sadeghpour, A. and Samiei, N. and Farahani, M.M. and Sadr-Ameli, M.A. and Maleki, M. and Noohi, F. (2007) Prevalence of mechanical dyssynchrony in heart failure patients with different QRS durations. PACE - Pacing and Clinical Electrophysiology, 30 (5). pp. 616-622.
|
Text
heart failure patients.pdf Download (62kB) | Preview |
Abstract
Background: Cardiac resynchronization therapy (CRT) has emerged as an established therapy for congestive heart failure. However, up to 30 of patients fail to respond to CRT despite prolonged QRS. Objectives: This study aimed at defining the prevalence of interventricular and intraventricular dyssynchrony in heart failure patients with different QRS durations. Methods: A total of 123 consecutive patients with severe heart failure (LVEF < 35 and NYHA class III-IV) were prospectively evaluated using 12-lead electrocardiogram and complete echocardiographic examination including tissue Doppler imaging. Results: According to the QRS duration, 56 patients had a QRS duration �120 ms (Group 1), 33 patients had a QRS duration between 120 and 150 ms (Group 2), and 34 patients had a QRS duration �150 ms (Group 3). Intraventricular dyssynchrony was present in 36 of Group 1 patients, in 58 of Group 2 patients, and in 79 of Group 3 patients (P < 0.000). Linear regression demonstrated a weak relation between QRS and intraventricular dyssynchrony. A greater proportion of patients with interventricular dyssynchrony was observed in Group 3 or Group 2 compared to patients with normal QRS duration (32 in Group 1 vs. 51.5 in Group 2 vs. 76.5 in Group 3, P < 0.000). Linear regression demonstrated a significant relation between QRS duration and interventricular mechanical delay. Conclusions: Although both interventricular and intraventricular dyssynchrony increased with the increasing QRS duration, the correlation between intraventricular mechanical and electrical dyssynchrony was weak. The lack of intraventricular dyssynchrony in a fraction of patients with standard CRT indication by QRS duration may provide us insight into the nonresponders rates. © 2007, The Authors.
| Item Type: | Article |
|---|---|
| Additional Information: | cited By 41 |
| Uncontrolled Keywords: | adult; article; cardiac resynchronization therapy; congestive heart failure; controlled study; correlation analysis; disease severity; Doppler echography; echocardiography; electrocardiogram; female; heart electrophysiology; heart muscle conduction disturbance; human; linear regression analysis; major clinical study; male; prospective study; QRS complex; treatment indication; treatment response, Analysis of Variance; Chi-Square Distribution; Echocardiography, Doppler, Color; Electric Countershock; Electrocardiography; Female; Heart Failure, Congestive; Humans; Linear Models; Male; Middle Aged; Prevalence; Prospective Studies; Treatment Outcome |
| Subjects: | WG Cardiovascular System |
| Divisions: | School of Rehabilitation Sciences |
| Depositing User: | parto mrs bakhtminoo |
| Date Deposited: | 26 Feb 2019 10:55 |
| Last Modified: | 26 Feb 2019 10:55 |
| URI: | http://eprints.iums.ac.ir/id/eprint/11875 |
Actions (login required)
 |
View Item |
