Value of microvolt T-wave alternans for predicting patients who would benefit from implantable cardioverter-defibrillator therapy

Haghjoo, M. and Arya, A. and Sadr-Ameli, M.A. (2006) Value of microvolt T-wave alternans for predicting patients who would benefit from implantable cardioverter-defibrillator therapy. Cardiology in Review, 14 (4). pp. 173-179.

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Abstract

Despite considerable progress in the management of coronary artery disease and dilated cardiomyopathy, a substantial proportion of patients remains at the risk of life-threatening arrhythmic events. The Multicenter Automatic Defibrillator Implantation II and Sudden Cardiac Death Heart Failure studies have conclusively demonstrated that prophylactic implantable cardioverter-defibrillator (ICD) therapy reduces mortality among subjects with ischemic and nonischemic cardiomyopathy but at the expense of potentially unnecessary ICD implantation in a large percentage of patients. Microvolt T-wave alternans (MTWA), with a negative predictive value greater than 90, holds promise for selecting the patients who would likely and patients not likely to benefit from ICD implantation. Accurate identification of high-risk patients by noninvasive MTWA may allow for improved widespread screening for sudden death prevention in the general population. Copyright © 2006 by Lippincott Williams & Wilkins.

Item Type: Article
Additional Information: cited By 2
Uncontrolled Keywords: cardiovascular risk; clinical trial; congestive cardiomyopathy; defibrillator; heart beat; heart infarction; high risk patient; human; ischemic heart disease; patient identification; patient selection; prognosis; review; screening; sudden death; T wave amplitude; congestive cardiomyopathy; defibrillator; heart function test; pathophysiology; prediction and forecasting; risk assessment, Cardiomyopathy, Dilated; Death, Sudden, Cardiac; Defibrillators, Implantable; Electrophysiologic Techniques, Cardiac; Humans; Predictive Value of Tests; Risk Assessment
Subjects: WG Cardiovascular System
QV Pharmacology
Depositing User: Librarian Farzaneh Dini
Date Deposited: 08 Apr 2020 05:22
Last Modified: 08 Apr 2020 05:22
URI: http://eprints.iums.ac.ir/id/eprint/11976

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