Distribution frequency of hepatitis C virus genotypes in 2231 patients in Iran

Keyvani, H. and Alizadeh, A.H.M. and Alavian, S.M. and Ranjbar, M. and Hatami, S. (2007) Distribution frequency of hepatitis C virus genotypes in 2231 patients in Iran. Hepatology Research, 37 (2). pp. 101-103.

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Aim: Given the importance of frequency distribution of HCV genotypes, we studied genotypic distribution of HCV in Iran. In this cross-sectional study, 2231 patients with hepatitis C who presented in hepatitis clinics in Tehran were investigated for HCV genotypes. Methods: Genotyping was performed by genotype specific primers. Results: The highest frequency was for genotype 1a, with 886 (39.7) of subjects. Genotype 3a and 1b were the other frequent genotypes, with 613 (27.5) and 271 (12.1) subjects, respectively. Of the samples, 401 (18) had an undetermined genotype. Mixed genotypes were also found in 33 samples (1.6). Genotype 1b frequency in patients under 20 years old was 10.2, while its frequency in patients over 60 years old was 18.5. Genotype 1b frequency significantly increased by age (P=0.02). Conclusion: This study indicates that the dominant HCV genotype among patients living in Tehran was 1a. © 2007 The Japan Society of Hepatology.

Item Type: Article
Additional Information: cited By 43
Uncontrolled Keywords: complementary DNA; hepatitis C antibody; RNA, adolescent; adult; age; aged; article; blood sampling; child; controlled study; cross-sectional study; DNA synthesis; female; gene frequency; genotype; health care facility; hepatitis C; Hepatitis C virus; human; human cell; Iran; major clinical study; male; polymerase chain reaction; priority journal
Subjects: WC Communicable Diseases
Divisions: School of Rehabilitation Sciences
Depositing User: parto mrs bakhtminoo
Date Deposited: 26 Feb 2019 11:18
Last Modified: 26 Feb 2019 11:18
URI: http://eprints.iums.ac.ir/id/eprint/12256

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