Epistatic interaction between adiponectin and survivin gene polymorphisms in endometrial carcinoma

Aminimoghaddam, S. and Shahrabi-Farahani, M. and Mohajeri-Tehrani, M. and Amiri, P. and Fereidooni, F. and Larijani, B. and Shafiee, G. and Amoli, M.M. (2007) Epistatic interaction between adiponectin and survivin gene polymorphisms in endometrial carcinoma. Pathology Research and Practice, 211 (4). pp. 293-297.

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Adiponectin appears to play an important role in the development and progression of several obesity-related malignancies. Also, overexpression of survivin, an inhibitor of apoptosis protein, is associated with increased risk of cancers. The aim of this study was to investigate the association between two polymorphisms in the adiponectin gene and endometrial cancer (EC) risk. We also investigated whether epistasis between surviving and adiponectin gene polymorphisms are associated with EC risk in an Iranian population.The samples comprised formalin-fixed, paraffin-embedded tissue sections obtained from the archive of the pathology department, Imam-Khomeini Hospital and Firouzgar hospital. After DNA extraction the genotyping was performed using PCR-RFLP technique.Single nucleotide polymorphisms (SNPs) in adiponectin (rs1063539, rs2241766) and survivin (rs9904341) gene were evaluated in the study. The increased frequency of ADIPOQ rs1063539C allele (CC. +. CG genotype) was associated with decreased EC risk OR: 0.39(0.17-0.90). Survivin rs9904341C allele (CC. +. CG genotype) was associated with increased EC risk crude OR: 2.75(1.27-5.95), adjusted OR: 2.93(1.27-6.76). We observed an epistatic interaction between survivin rs9904341 CC. +. CG genotype and ADIPOQ rs1063539 GG genotype increasing the risk of EC compared to those with other genotypes OR: 4.86(1.88-12.54), P=0.001.Our findings indicate that adiponectin might have a modulatory effect on survivin role and function in EC, which requires further investigation. © 2014 Elsevier GmbH.

Item Type: Article
Additional Information: cited By 7
Uncontrolled Keywords: adiponectin; survivin; adiponectin; ADIPOQ protein, human; BIRC5 protein, human; inhibitor of apoptosis protein, adiponectin gene; adult; allele; Article; cancer risk; controlled study; disease association; DNA base composition; DNA extraction; endometrium carcinoma; epistasis; female; gene frequency; gene interaction; genetic association; genotype; human; Iranian people; major clinical study; polymerase chain reaction; restriction fragment length polymorphism; risk reduction; single nucleotide polymorphism; survivin gene; upregulation; aged; cross-sectional study; endometrium tumor; genetic polymorphism; genetic predisposition; genetics; middle aged; risk; single nucleotide polymorphism, Adiponectin; Aged; Cross-Sectional Studies; Endometrial Neoplasms; Epistasis, Genetic; Female; Gene Frequency; Genetic Predisposition to Disease; Genotype; Humans; Inhibitor of Apoptosis Proteins; Middle Aged; Polymorphism, Genetic; Polymorphism, Restriction Fragment Length; Polymorphism, Single Nucleotide; Risk
Subjects: WP Gynecology
Divisions: School of Rehabilitation Sciences
Depositing User: parto mrs bakhtminoo
Date Deposited: 26 Feb 2019 11:19
Last Modified: 26 Feb 2019 11:19
URI: http://eprints.iums.ac.ir/id/eprint/12258

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