Development and characterization of a novel conductive polyaniline-g-polystyrene/Fe 3 O 4 nanocomposite for the treatment of cancer

Ahmadkhani, L. and Mostafavi, E. and Ghasemali, S. and Baghban, R. and Pazoki-Toroudi, H. and Davaran, S. and Malakootikhah, J. and Asadi, N. and Mammadova, L. and Saghfi, S. and Webster, T.J. and Akbarzadeh, A. (2019) Development and characterization of a novel conductive polyaniline-g-polystyrene/Fe 3 O 4 nanocomposite for the treatment of cancer. Artificial Cells, Nanomedicine and Biotechnology, 47 (1). pp. 873-881.

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Abstract

The goal of this study is to synthesize, characterize and investigate some physicochemical properties of conductive polyaniline-g-polystyrene/Fe 3 O 4 (Fe 3 O 4 /PSt-g-PANi) nanocomposites. For this purpose, initially, Fe 3 O 4 nanoparticles were synthesized by a co-precipitation method. Then, the desired nanocomposite was synthesized in two steps. First, the atom transfer radical polymerization (ATRP) of styrene was performed using an ATRP initiator attached to the surface of Fe 3 O 4 nanoparticles, followed by functionalization of the Fe 3 O 4 -PSt with amine groups (�NH 2 ). Second, surface oxidative graft copolymerization of aniline was accomplished using the �NH 2 moieties on the Fe 3 O 4 /PSt-NH 2 as the anchoring sites. The prepared materials were characterized by various instruments, including TEM, SEM, TGA, EDX, FT-IR, XRD and conductivity measurements. The results indicated that the synthesized conductive polymer/Fe 3 O 4 nanocomposites had higher electrical conductivity and thermal resistance than those of the corresponding homopolymers. © 2019, © 2019 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

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