Saghazadeh, A. and Ataeinia, B. and Keynejad, K. and Abdolalizadeh, A. and Hirbod-Mobarakeh, A. and Rezaei, N. (2019) Anti-inflammatory cytokines in autism spectrum disorders: A systematic review and meta-analysis. Cytokine, 123.
Full text not available from this repository.Abstract
Background: In the search for the causes of autism spectrum disorders (ASD), inflammatory markers have emerged as potential candidates. The present meta-analysis was performed on studies examining circulating concentrations of anti-inflammatory cytokines in people with ASD compared with control subjects without ASD. Methods: We identified potentially eligible studies by systematically searching electronic databases from inception to February 2018. Results: Twenty-five studies with a total of 1754 participants (1022 patients with ASD and 732 control subjects) were included in the mate-analysis; 4 for interferon (IFN)-α, 9 for interleukin (IL)-1 receptor antagonist (Ra), 9 for IL-4, 6 for IL-5, 3 for IL-9, 14 for IL-10, 7 for IL-13, and 6 for transforming growth factor (TGF)-β. We found a moderate decrease in plasma levels of IL-10 (SMD = �0.59) and a small decrease in serum levels of IL-1Ra (SMD = �0.25) in patients with ASD. On the contrary, serum IL-5 levels were slightly increased (SMD = 0.26) in these patients. We conducted meta-regression analyses to investigate the possible effect of moderatos on the effect size (ES) of difference in mean levels of IL-10. Difference in the mean age between patients and controls showed a negative influence on the ES and was able to explain about 0.4 of total between-study variance. In contrast, latitude exerted a positive effect on the ES and explained a lower proportion (0.1) of total between-study variance. Conclusions: This meta-analysis provides evidence for the lower concentration of anti-inflammatory cytokines IL-10 and IL-1Ra in autistic patients compared with control subjects. Also, meta-regression analyses point to the interaction of latitude, age, and gender with peripheral alterations of associated anti-inflammatory cytokines. © 2019 Elsevier Ltd
| Item Type: | Article |
|---|---|
| Additional Information: | cited By 0 |
| Subjects: | WL Nervous System |
| Depositing User: | eprints admin |
| Date Deposited: | 23 Sep 2020 08:49 |
| Last Modified: | 23 Sep 2020 08:49 |
| URI: | http://eprints.iums.ac.ir/id/eprint/13267 |
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