Discrepancies of Notch 1 receptor during development of chronic seizures

Saffarzadeh, F. and Modarres Mousavi, S.M. and Lotfinia, A.A. and Alipour, F. and Hosseini Ravandi, H. and Karimzadeh, F. (2019) Discrepancies of Notch 1 receptor during development of chronic seizures. Journal of Cellular Physiology, 234 (8). pp. 13773-13780.

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The critical role of Notch signaling has been shown in the pathogenesis of some neurological disorders including schizophrenia, epilepsy and Alzheimer�s disease. This study was aimed to evaluate the role of Notch 1 receptor in epileptogenesis as well as seizure characteristics. The animals were divided into three groups of sham, early stage and end stage. In sham group: Normal saline was injected intraperitoneally (ip) in the same as protocol of pentylenetetrazol (PTZ) injection. PTZ was injected (ip) every 48 hr over a period of 1 week in the group of early stage and over a period of 4 weeks in the end stage. The gene expression as well as distribution of Notch 1 receptor was assessed in the parietal cortex and hippocampus. In addition, the effect of agonist or antagonist of Notch 1 receptor was assessed on the epileptic discharges induced by PTZ injection. The gene expression of Notch 1 decreased in the hippocampus significantly in the end-stage group compared with sham, and early groups. Furthermore, distribution of Notch 1 receptor increased in the somatosensory cortex and decreased in the CA1 hippocampal area in the end-stage group. Intraventricular microinjection of Notch 1 agonist significantly increased the amplitude as well as frequency of spikes and decreased the latency of first epileptic discharges. Our findings illustrate the critical role of Notch signalling as a potential pathway in the epileptogenesis during development of chronic seizures. © 2019 Wiley Periodicals, Inc.

Item Type: Article
Additional Information: cited By 0
Subjects: WL Nervous System
Depositing User: eprints admin
Date Deposited: 23 Sep 2020 10:14
Last Modified: 23 Sep 2020 10:14
URI: http://eprints.iums.ac.ir/id/eprint/13312

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