Abdollahi, H. and Tanha, K. and Mofid, B. and Razzaghdoust, A. and Saadipoor, A. and Khalafi, L. and Bakhshandeh, M. and Mahdavi, S.R. (2019) MRI Radiomic Analysis of IMRT-Induced Bladder Wall Changes in Prostate Cancer Patients: A Relationship with Radiation Dose and Toxicity. Journal of Medical Imaging and Radiation Sciences, 50 (2). pp. 252-260.
Full text not available from this repository.Abstract
Background: The main purpose of this study was to assess the structural changes in the bladder wall of prostate cancer patients treated with intensity-modulated radiation therapy using magnetic resonance imaging texture features analysis and to correlate image texture changes with radiation dose and urinary toxicity. Methods: Ethical clearance was granted to enroll 33 patients into this study who were treated with intensity-modulated radiation therapy for prostate cancer. All patients underwent two magnetic resonance imagings before and after radiation therapy (RT). A total of 274 radiomic features were extracted from MR-T2W�weighted images. Wilcoxon singed rank-test was performed to assess significance of the change in mean radiomic features post-RT relative to pre-RT values. The relationship between radiation dose and feature changes was assessed and depicted. Cystitis was recorded as urinary toxicity. Area under receiver operating characteristic curve of a logistic regression�based classifier was used to find correlation between radiomic features with significant changes and radiation toxicity. Results: Thirty-three bladder walls were analyzed, with 11 patients developing grade �2 urinary toxicity. We showed that radiomic features may predict radiation toxicity and features including S5.0SumVarnc, S2.2SumVarnc, S1.0AngScMom, S0.4SumAverg, and S5. 5InvDfMom with area under receiver operating characteristic curve 0.75, 0.69, 0.65, 0.63, and 0.62 had highest correlation with toxicity, respectively. The results showed that most of the radiomic features were changed with radiation dose. Conclusion: Feature changes have a good correlation with radiation dose and radiation-induced urinary toxicity. These radiomic features can be identified as being potentially important imaging biomarkers and also assessing mechanisms of radiation-induced bladder injuries. © 2019
| Item Type: | Article |
|---|---|
| Additional Information: | cited By 0 |
| Subjects: | WJ Urogenital System QZ Pathology |
| Depositing User: | eprints admin |
| Date Deposited: | 05 Oct 2020 10:37 |
| Last Modified: | 05 Oct 2020 10:37 |
| URI: | http://eprints.iums.ac.ir/id/eprint/13453 |
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