Melatonin, a toll-like receptor inhibitor: Current status and future perspectives

Tamtaji, O.R. and Mobini, M. and Reiter, R.J. and Azami, A. and Gholami, M.S. and Asemi, Z. (2019) Melatonin, a toll-like receptor inhibitor: Current status and future perspectives. Journal of Cellular Physiology, 234 (6). pp. 7788-7795.

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Abstract

Toll-like receptors (TLRs) are crucial activators of inflammatory responses, they are considered immune receptors. TLRs are of fundamental importance in the pathophysiology of disorders related to inflammation including neurodegenerative diseases and cancer. Melatonin is a beneficial agent in the treatment of inflammatory and immune disorders. Melatonin is potent anti-inflammatory hormone that regulates various molecular pathways. Withal, limited studies have evaluated the inhibitory role of melatonin on TLRs. This review summarizes the current knowledge related to the effects of melatonin on TLRs in some common inflammatory and immunity disorders. © 2018 Wiley Periodicals, Inc.

Item Type: Article
Additional Information: cited By 1
Subjects: WL Nervous System
WW Ophthalmology
QV Pharmacology
Depositing User: eprints admin
Date Deposited: 06 Oct 2020 05:08
Last Modified: 06 Oct 2020 05:08
URI: http://eprints.iums.ac.ir/id/eprint/13470

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