Staphylococcus aureus versus neutrophil: Scrutiny of ancient combat

Nasser, A. and Moradi, M. and Jazireian, P. and Safari, H. and Alizadeh-Sani, M. and Pourmand, M.R. and Azimi, T. (2019) Staphylococcus aureus versus neutrophil: Scrutiny of ancient combat. Microbial Pathogenesis, 131. pp. 259-269.

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Staphylococcus aureus (S.aureus)is a Gram-positive bacterium that causes many infections and diseases. This pathogen can cause many types of infections such as impetigo, toxic shock syndrome toxin (TSST1), pneumonia, endocarditis, and autoimmune diseases like lupus erythematosus and can infect other healthy individuals. In the pathogenic process, colonization is a main risk factor for invasive diseases. Various factors including the cell wall-associated factors and receptors of the epithelial cells facilitate adhesion and colonization of this pathogen. S. aureus has many enzymes, toxins, and strategies to evade from the immune system either by an enzyme that lyses cellular component or by hiding from the immune system via surface antigens like protein A and second immunoglobulin-binding protein (Sbi). The strategies of this bacterium can be divided into five groups: A: Inhibit neutrophil recruitment B: Inhibit phagocytosis C: Inhibit killing by ROS, D: Neutrophil killing, and E: Resistance to antimicrobial peptide. On the other hand, innate immune system via neutrophils, the most important polymorphonuclear leukocytes, fights against bacterial cells by neutrophil extracellular trap (NET). In this review, we try to explain the role of each factor in immune evasion. © 2019 Elsevier Ltd

Item Type: Article
Additional Information: cited By 0
Subjects: QW Microbiology. Immunology
Depositing User: eprints admin
Date Deposited: 06 Oct 2020 05:13
Last Modified: 06 Oct 2020 05:13

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