Abed, Z. and Beik, J. and Laurent, S. and Eslahi, N. and Khani, T. and Davani, E.S. and Ghaznavi, H. and Shakeri-Zadeh, A. (2019) Iron oxide�gold core�shell nano-theranostic for magnetically targeted photothermal therapy under magnetic resonance imaging guidance. Journal of Cancer Research and Clinical Oncology, 145 (5). pp. 1213-1219.
Full text not available from this repository.Abstract
Recent efforts in the area of photothermal therapy (PTT) follow two important aims: (i) selective targeting of plasmonic nanoparticles to the tumor and (ii) real-time guidance of PTT operation through employing multimodal imaging modalities. In the present study, we utilized a multifunctional theranostic nanoplatform constructed from iron (III) oxide�gold (Fe 2 O 3 @Au) core�shell nanoparticles to fulfill these aims. The Au shell exhibits surface plasmon resonance, a property that is exploited to realize PTT. The magnetic core enables Fe 2 O 3 @Au to be employed as a magnetic resonance imaging (MRI) contrast agent. Furthermore, the magnetic core has the potential to establish a magnetic drug targeting strategy through which Fe 2 O 3 @Au can be directed to the tumor site by means of magnetic field. To test these potentials, Balb/c mice bearing CT26 colorectal tumor model were intravenously injected with Fe 2 O 3 @Au. Immediately after injection, a magnet was placed on the tumor site for 3 h to concentrate nanoparticles, followed by the near infrared (NIR) laser irradiation. MRI study confirmed the accumulation of nanoparticles within the tumor due to T2 enhancement capability of Fe 2 O 3 @Au. The in vivo thermometry results demonstrated that the tumors in magnetic targeting group had a significantly higher temperature elevation rate upon NIR irradiation than non-targeted group (~ 12 °C vs. 8.5 °C). The in vivo antitumor assessment revealed that systemic injection of Fe 2 O 3 @Au in combination with magnetic targeting and NIR irradiation resulted in complete remission of tumor growth. Therefore, Fe 2 O 3 @Au can establish a targeted PTT strategy for efficient eradication of tumor cells under the guidance of MRI. © 2019, Springer-Verlag GmbH Germany, part of Springer Nature.
| Item Type: | Article |
|---|---|
| Additional Information: | cited By 0 |
| Subjects: | WN Radiology. Diagnostic Imaging QZ Pathology |
| Depositing User: | eprints admin |
| Date Deposited: | 06 Oct 2020 07:04 |
| Last Modified: | 06 Oct 2020 07:04 |
| URI: | http://eprints.iums.ac.ir/id/eprint/13514 |
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